TY - JOUR
T1 - Moderate Intensity Resistive Training Reduces Oxidative Stress and Improves Muscle Mass and Function in Older Individuals
AU - Vezzoli, Alessandra
AU - Mrakic-Sposta, Simona
AU - Montorsi, Michela
AU - Porcelli, Simone
AU - Vago, Paola
AU - Cereda, Ferdinando
AU - Longo, Stefano
AU - Maggio, Marcello
AU - Narici, Marco
PY - 2019
Y1 - 2019
N2 - An innovative moderate-intensity resistive exercise-training (RT) program was tested in
thirty-five sarcopenic elders (SAR). The subjects were randomized into two groups: SAR training
(SAR-RT), n = 20, 73.0 5.5 years, or SAR non-training (SAR-NT), n = 15, 71.7 3.4 years. The training
consisted of 12-week progressive RT, thrice/week, at 60% one-repetition maximum (1RM), 3 sets,
14–16 repetitions for both upper and lower limbs. The pre and post intervention measurements
included: the skeletal muscle index (SMI%); strength (1RM); stair-climbing power (SCP); muscle
thickness (MT) of vastus lateralis (VL) and elbow flexors (EF), VL pennation angle (PA), rectus
femoris (RF) anatomical cross-sectional area (ACSA); reactive oxygen species (ROS), total antioxidant
capacity (TAC), protein carbonyls (PC), thiobarbituric acid-reactive substances (TBARS), 8-isoprostane
(8-iso-PGF2-), 8-OH-2-deoxyguanosine (8-OH-dG), as markers of oxidative stress/damage (OxS).
In SAR-RT, SCP increased by 7.7% (P < 0.01), MT increased by 5.5% for VL, 10.4% for EF and PA
increased by 13.4% for VL (P < 0.001 for all). The RF ACSA increased by 14.5% (P < 0.001). 1RM
significantly increased by at least 67% for all muscles tested. Notably muscle strength (1RM) positively
correlated (P < 0.001) with TAC and negatively with PC (P < 0.001). In conclusion, moderate intensity
RT is an eective strategy to increase muscle mass and strength in SAR, while minimizing OxS.
AB - An innovative moderate-intensity resistive exercise-training (RT) program was tested in
thirty-five sarcopenic elders (SAR). The subjects were randomized into two groups: SAR training
(SAR-RT), n = 20, 73.0 5.5 years, or SAR non-training (SAR-NT), n = 15, 71.7 3.4 years. The training
consisted of 12-week progressive RT, thrice/week, at 60% one-repetition maximum (1RM), 3 sets,
14–16 repetitions for both upper and lower limbs. The pre and post intervention measurements
included: the skeletal muscle index (SMI%); strength (1RM); stair-climbing power (SCP); muscle
thickness (MT) of vastus lateralis (VL) and elbow flexors (EF), VL pennation angle (PA), rectus
femoris (RF) anatomical cross-sectional area (ACSA); reactive oxygen species (ROS), total antioxidant
capacity (TAC), protein carbonyls (PC), thiobarbituric acid-reactive substances (TBARS), 8-isoprostane
(8-iso-PGF2-), 8-OH-2-deoxyguanosine (8-OH-dG), as markers of oxidative stress/damage (OxS).
In SAR-RT, SCP increased by 7.7% (P < 0.01), MT increased by 5.5% for VL, 10.4% for EF and PA
increased by 13.4% for VL (P < 0.001 for all). The RF ACSA increased by 14.5% (P < 0.001). 1RM
significantly increased by at least 67% for all muscles tested. Notably muscle strength (1RM) positively
correlated (P < 0.001) with TAC and negatively with PC (P < 0.001). In conclusion, moderate intensity
RT is an eective strategy to increase muscle mass and strength in SAR, while minimizing OxS.
KW - exercise education
KW - muscle strength
KW - old people
KW - resistive training
KW - exercise education
KW - muscle strength
KW - old people
KW - resistive training
UR - http://hdl.handle.net/10807/142854
UR - https://www.mdpi.com/2076-3921/8/10/431
U2 - 10.3390/antiox8100431
DO - 10.3390/antiox8100431
M3 - Article
SN - 2076-3921
VL - 8
SP - 1
EP - 17
JO - Antioxidants
JF - Antioxidants
ER -