MMP-7 and MMP-9 are overexpressed in the synovial tissue from severe temporomandibular joint dysfunction

Carla Loreto; Veronica Filetti; Luis Eduardo Almeida; Giusy Rita Maria La Rosa; Rosalia Leonardi; Cristina Grippaudo; Antonino Lo Giudice

MMP-7 and MMP-9 are overexpressed in the synovial tissue from severe temporomandibular joint dysfunction

Carla Loreto, Veronica Filetti, Luis Eduardo Almeida, Giusy Rita Maria La Rosa, Rosalia Leonardi, Cristina Grippaudo, Antonino Lo Giudice

Risultato della ricerca: Contributo in rivista › Articolo in rivista › peer review

10 Citazioni (Scopus)

Abstract

Matrix metalloproteinases (MMPs) are tissue-enzymes that play a key role during the remodeling process, such as in inflammatory diseases. MMP-7 and MMP-9 have been shown to be implicated in extracellular matrix homeostasis and in joint disc remodeling. The objective of this study was to determine the relation of MMP-7 and MMP-9 expression with severe temporomandibular joint dysfunction, in particular with anterior disk displacement without reduction (ADDwoR), using an immunohistochemical approach. Therefore, twenty human temporomandibular synovia in the test group and ten in the control group were collected. The results showed there was a statistically significant difference (P<0.001) for morphometric and densitometric analysis of both detected MMPs in control and test groups. In conclusion, MMP-7 and MMP-9 were overexpressed in the synovial tissue of patients with ADDwoR.

Lingua originale	English
pagine (da-a)	8-12
Numero di pagine	5
Rivista	European Journal of Histochemistry
Volume	2020
Stato di pubblicazione	Pubblicato - 2020

Keywords

MMP-7
MMP-9

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title = "MMP-7 and MMP-9 are overexpressed in the synovial tissue from severe temporomandibular joint dysfunction",

abstract = "Matrix metalloproteinases (MMPs) are tissue-enzymes that play a key role during the remodeling process, such as in inflammatory diseases. MMP-7 and MMP-9 have been shown to be implicated in extracellular matrix homeostasis and in joint disc remodeling. The objective of this study was to determine the relation of MMP-7 and MMP-9 expression with severe temporomandibular joint dysfunction, in particular with anterior disk displacement without reduction (ADDwoR), using an immunohistochemical approach. Therefore, twenty human temporomandibular synovia in the test group and ten in the control group were collected. The results showed there was a statistically significant difference (P<0.001) for morphometric and densitometric analysis of both detected MMPs in control and test groups. In conclusion, MMP-7 and MMP-9 were overexpressed in the synovial tissue of patients with ADDwoR.",

keywords = "MMP-7, MMP-9, MMP-7, MMP-9",

author = "Carla Loreto and Veronica Filetti and Almeida, {Luis Eduardo} and {La Rosa}, {Giusy Rita Maria} and Rosalia Leonardi and Cristina Grippaudo and Giudice, {Antonino Lo}",

year = "2020",

language = "English",

volume = "2020",

pages = "8--12",

journal = "European Journal of Histochemistry",

issn = "1121-760X",

publisher = "Tipolitografia l Ponzio:Viale Montegrappa 2, I 27100 Pavia Italy:011 39 0382 576600, Fax: 011 39 0382 574200",

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TY - JOUR

T1 - MMP-7 and MMP-9 are overexpressed in the synovial tissue from severe temporomandibular joint dysfunction

AU - Loreto, Carla

AU - Filetti, Veronica

AU - Almeida, Luis Eduardo

AU - La Rosa, Giusy Rita Maria

AU - Leonardi, Rosalia

AU - Grippaudo, Cristina

AU - Giudice, Antonino Lo

PY - 2020

Y1 - 2020

N2 - Matrix metalloproteinases (MMPs) are tissue-enzymes that play a key role during the remodeling process, such as in inflammatory diseases. MMP-7 and MMP-9 have been shown to be implicated in extracellular matrix homeostasis and in joint disc remodeling. The objective of this study was to determine the relation of MMP-7 and MMP-9 expression with severe temporomandibular joint dysfunction, in particular with anterior disk displacement without reduction (ADDwoR), using an immunohistochemical approach. Therefore, twenty human temporomandibular synovia in the test group and ten in the control group were collected. The results showed there was a statistically significant difference (P<0.001) for morphometric and densitometric analysis of both detected MMPs in control and test groups. In conclusion, MMP-7 and MMP-9 were overexpressed in the synovial tissue of patients with ADDwoR.

AB - Matrix metalloproteinases (MMPs) are tissue-enzymes that play a key role during the remodeling process, such as in inflammatory diseases. MMP-7 and MMP-9 have been shown to be implicated in extracellular matrix homeostasis and in joint disc remodeling. The objective of this study was to determine the relation of MMP-7 and MMP-9 expression with severe temporomandibular joint dysfunction, in particular with anterior disk displacement without reduction (ADDwoR), using an immunohistochemical approach. Therefore, twenty human temporomandibular synovia in the test group and ten in the control group were collected. The results showed there was a statistically significant difference (P<0.001) for morphometric and densitometric analysis of both detected MMPs in control and test groups. In conclusion, MMP-7 and MMP-9 were overexpressed in the synovial tissue of patients with ADDwoR.

KW - MMP-7

KW - MMP-9

KW - MMP-7

KW - MMP-9

UR - http://hdl.handle.net/10807/151171

M3 - Article

SN - 1121-760X

VL - 2020

SP - 8

EP - 12

JO - European Journal of Histochemistry

JF - European Journal of Histochemistry

ER -

MMP-7 and MMP-9 are overexpressed in the synovial tissue from severe temporomandibular joint dysfunction

Abstract

Keywords

OSS delle Nazioni Unite

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