Mixed, melancholic, and anxious features in depression: a cross-sectional study of sociodemographic and clinical correlates

Luigi Janiri, Daniel Souery, Raffaella Calati, Paolo Scudellari, Stuart Montgomery, Siegfried Kasper, Joseph Zohar, Julien Mendlewicz, Alessandro Serretti

Risultato della ricerca: Contributo in rivistaArticolo in rivista

7 Citazioni (Scopus)

Abstract

Major depression (MD) is currently viewed as a heterogeneous condition, characterized by different psychopathological dimensions.METHODS: Our sample was composed of 1,289 nonpsychotic bipolar/unipolar depressed patients. Participants were divided into mixed (MXD), melancholic (MEL), and anxious (ANX) depressed, according to a hierarchical functional model. Sociodemographic and clinical variables were compared across depressive subtypes by χ2 test and analysis of variance. The Young Mania Rating Scale (YMRS) and 2 subscales (melancholic [MEL-S] and psychic-somatic anxiety [PSOM-ANX]) from the Hamilton Depression Rating Scale also served as continuous outcome measures. RESULTS: MXD patients more frequently had bipolar I disorder (BD I), younger age of onset, and a higher familial load for mood disorders. MEL and ANX patients were more frequently diagnosed with major depressive disorder and reported a higher suicide risk. YMRS scores in depression was associated with BD I diagnosis (P < .0001) and manic polarity of the last episode (P < .0001), while a depressive polarity of the last episode (P < .0001) was associated with higher MEL-S score. No specific predictor was associated with PSOM-ANX score. CONCLUSIONS: Overall, our findings suggest that mixed depressive features are associated with significant hallmarks of bipolarity, and melancholic features may be influenced by previous depressive polarity. The symptom domain of anxiety appears to have no specific predictor.
Lingua originaleEnglish
pagine (da-a)243-253
Numero di pagine11
RivistaAnnals of Clinical Psychiatry
Volume26
Stato di pubblicazionePubblicato - 2014

Keywords

  • major depression

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