TY - JOUR
T1 - Mitochondrial network genes in the skeletal muscle of amyotrophic lateral sclerosis patients.
AU - Bernardini, Camilla
AU - Censi, Federica
AU - Lattanzi, Wanda
AU - Barba, Marta
AU - Calcagnini, Giovanni
AU - Giuliani, Alessandro
AU - Tasca, Giorgio
AU - Sabatelli, Mario
AU - Ricci, Enzo
AU - Michetti, Fabrizio
PY - 2013
Y1 - 2013
N2 - Recent evidence suggested that muscle degeneration might lead and/or contribute to neurodegeneration, thus it possibly play a key role in the etiopathogenesis and progression of amyotrophic lateral sclerosis (ALS). To test this hypothesis, this study attempted to categorize functionally relevant genes within the genome-wide expression profile of human ALS skeletal muscle, using microarray technology and gene regulatory network analysis. The correlation network structures significantly change between patients and controls, indicating an increased inter-gene connection in patients compared to controls. The gene network observed in the ALS group seems to reflect the perturbation of muscle homeostasis and metabolic balance occurring in affected individuals. In particular, the network observed in the ALS muscles includes genes (PRKR1A, FOXO1, TRIM32, ACTN3, among others), whose functions connect the sarcomere integrity to mitochondrial oxidative metabolism. Overall, the analytical approach used in this study offer the possibility to observe higher levels of correlation (i.e. common expression trends) among genes, whose function seems to be aberrantly activated during the progression of muscle atrophy.
AB - Recent evidence suggested that muscle degeneration might lead and/or contribute to neurodegeneration, thus it possibly play a key role in the etiopathogenesis and progression of amyotrophic lateral sclerosis (ALS). To test this hypothesis, this study attempted to categorize functionally relevant genes within the genome-wide expression profile of human ALS skeletal muscle, using microarray technology and gene regulatory network analysis. The correlation network structures significantly change between patients and controls, indicating an increased inter-gene connection in patients compared to controls. The gene network observed in the ALS group seems to reflect the perturbation of muscle homeostasis and metabolic balance occurring in affected individuals. In particular, the network observed in the ALS muscles includes genes (PRKR1A, FOXO1, TRIM32, ACTN3, among others), whose functions connect the sarcomere integrity to mitochondrial oxidative metabolism. Overall, the analytical approach used in this study offer the possibility to observe higher levels of correlation (i.e. common expression trends) among genes, whose function seems to be aberrantly activated during the progression of muscle atrophy.
KW - amyotrophic lateral sclerosis
KW - amyotrophic lateral sclerosis
UR - http://hdl.handle.net/10807/41455
U2 - doi: 10.1371/journal.pone.0057739
DO - doi: 10.1371/journal.pone.0057739
M3 - Article
SN - 1932-6203
VL - 2013
SP - N/A-N/A
JO - PLoS One
JF - PLoS One
ER -