Mitochondrial dysfunction and aging: Insights from the analysis of extracellular vesicles

Anna Rita Bentivoglio, Francesco Landi, Roberto Bernabei, Emanuele Marzetti, Riccardo Calvani, Maria Rita Lo Monaco, Flora Guerra, Cecilia Bucci

Risultato della ricerca: Contributo in rivistaArticolo in rivista

29 Citazioni (Scopus)


The progressive decline of cell function and integrity, manifesting clinically as increased vulnerability to adverse outcomes and death, is core to biological aging. Mitochondrial dysfunction, oxidative stress, altered intercellular communication (including chronic low-grade inflammation), genomic instability, telomere attrition, loss of proteostasis, altered nutrient sensing, epigenetic alterations, and stem cell exhaustion have been proposed as hallmarks of aging. These “aging pillars” are not mutually exclusive, making the matter intricate and leaving numerous unanswered questions. The characterization of circulating extracellular vesicles (EVs) has recently allowed specific secretory phenotypes associated with aging to be identified. As such, EVs may serve as novel biomarkers for capturing the complexity of aging. Besides the mitochondrial–lysosomal axis, EV trafficking has been proposed as an additional layer in mitochondrial quality control. Indeed, disruption of the mitochondrial–lysosomal axis coupled with abnormal EV secretion may play a role in the pathogenesis of aging and several disease conditions. Here, we discuss (1) the mechanisms of EV generation; (2) the relationship between the mitochondrial–lysosomal axis and EV trafficking in the setting of mitochondrial quality control; and (3) the prospect of using EVs as aging biomarkers and as delivery systems for therapeutics against age-related conditions.
Lingua originaleEnglish
pagine (da-a)1-12
Numero di pagine12
RivistaInternational Journal of Molecular Sciences
Stato di pubblicazionePubblicato - 2019


  • Biomarkers
  • Catalysis
  • Computer Science Applications1707 Computer Vision and Pattern Recognition
  • Exosomes
  • Inorganic Chemistry
  • Mitochondrial biogenesis
  • Mitochondrial dynamics
  • Mitochondrial quality control
  • Mitochondrial-derived vesicles (MDVs)
  • Mitochondrial-lysosomal axis
  • Mitophagy
  • Molecular Biology
  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Spectroscopy


Entra nei temi di ricerca di 'Mitochondrial dysfunction and aging: Insights from the analysis of extracellular vesicles'. Insieme formano una fingerprint unica.

Cita questo