Mitochondrial Alterations and Signaling in Aging, Frailty, and Sarcopenia: An Integrated View

Anna Picca, Marta Gonzalez-Freire, Stephen D. Anton, Emanuele Marzetti, Christiaan Leeuwenburgh

Risultato della ricerca: Contributo in libroChapter


Aging, a highly complex and multifactorial process, can be framed as a physiological mismatch resulting from decreasing resilience and increasing levels of damage generation and accumulation. Intrinsic drivers of human aging have been discovered and attributed a role in the pathogenesis of frailty and sarcopenia. Mitochondrial function and signaling are in the spotlight as relevant mechanisms of aging. Declines in functional health are a frequent trait of old age and a major factor limiting independence in late life. Measures of physical performance are also metrics of aging as they can predict incident disability and other health-related negative events. The integration of measures of mitochondrial biology and other hallmarks of aging allows a comprehensive appraisal of the events underlying the development and progression of frailty and sarcopenia.
Lingua originaleEnglish
Titolo della pubblicazione ospiteFrailty
EditorOlga Theou Jorge G. Ruiz
Numero di pagine5
Stato di pubblicazionePubblicato - 2024


  • Apoptosis
  • Mitophagy
  • Oxidative stress
  • Muscle wasting
  • Mitochondrial quality control


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