Mismatch Repair Deficiency as a Predictive and Prognostic Biomarker in Endometrial Cancer: A Review on Immunohistochemistry Staining Patterns and Clinical Implications

Francesca Addante; Antonio D’Amati; Angela Santoro; Giuseppe Angelico; Frediano Inzani; Damiano Arciuolo; Antonio Travaglino; Antonio Raffone; Nicoletta D'Alessandris; Giulia Scaglione; Michele Valente; Giordana Tinnirello; Stefania Sfregola; Belen Padial Urtueta; Angelo Piermattei; Federica Cianfrini; Antonino Mulè; Emma Bragantini; Gian Franco Zannoni

doi:10.3390/ijms25021056

Mismatch Repair Deficiency as a Predictive and Prognostic Biomarker in Endometrial Cancer: A Review on Immunohistochemistry Staining Patterns and Clinical Implications

Francesca Addante, Antonio D’Amati, Angela Santoro^*, Giuseppe Angelico, Frediano Inzani, Damiano Arciuolo, Antonio Travaglino, Antonio Raffone, Nicoletta D'Alessandris, Giulia Scaglione, Michele Valente, Giordana Tinnirello, Stefania Sfregola, Belen Padial Urtueta, Angelo Piermattei, Federica Cianfrini, Antonino Mulè, Emma Bragantini, Gian Franco Zannoni

^*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivista › Articolo in rivista

Abstract

Among the four endometrial cancer (EC) TCGA molecular groups, the MSI/hypermutated group represents an important percentage of tumors (30%), including different histotypes, and generally confers an intermediate prognosis for affected women, also providing new immunotherapeutic strategies. Immunohistochemistry for MMR proteins (MLH1, MSH2, MSH6 and PMS2) has become the optimal diagnostic MSI surrogate worldwide. This review aims to provide state-of-the-art knowledge on MMR deficiency/MSI in EC and to clarify the pathological assessment, interpretation pitfalls and reporting of MMR status.

Lingua originale	English
pagine (da-a)	1056-1062
Numero di pagine	7
Rivista	International Journal of Molecular Sciences
Volume	25
DOI	https://doi.org/10.3390/ijms25021056
Stato di pubblicazione	Pubblicato - 2024

Keywords

ENDOMETRIAL CANCER

OSS delle Nazioni Unite

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Addante, F., D’Amati, A., Santoro, A., Angelico, G., Inzani, F., Arciuolo, D., Travaglino, A., Raffone, A., D'Alessandris, N., Scaglione, G., Valente, M., Tinnirello, G., Sfregola, S., Padial Urtueta, B., Piermattei, A., Cianfrini, F., Mulè, A., Bragantini, E., & Zannoni, G. F. (2024). Mismatch Repair Deficiency as a Predictive and Prognostic Biomarker in Endometrial Cancer: A Review on Immunohistochemistry Staining Patterns and Clinical Implications. International Journal of Molecular Sciences, 25, 1056-1062. https://doi.org/10.3390/ijms25021056

@article{9bbb39bd74104416ac83934b256829a6,

title = "Mismatch Repair Deficiency as a Predictive and Prognostic Biomarker in Endometrial Cancer: A Review on Immunohistochemistry Staining Patterns and Clinical Implications",

abstract = "Among the four endometrial cancer (EC) TCGA molecular groups, the MSI/hypermutated group represents an important percentage of tumors (30%), including different histotypes, and generally confers an intermediate prognosis for affected women, also providing new immunotherapeutic strategies. Immunohistochemistry for MMR proteins (MLH1, MSH2, MSH6 and PMS2) has become the optimal diagnostic MSI surrogate worldwide. This review aims to provide state-of-the-art knowledge on MMR deficiency/MSI in EC and to clarify the pathological assessment, interpretation pitfalls and reporting of MMR status.",

keywords = "ENDOMETRIAL CANCER, ENDOMETRIAL CANCER",

author = "Francesca Addante and Antonio D{\textquoteright}Amati and Angela Santoro and Giuseppe Angelico and Frediano Inzani and Damiano Arciuolo and Antonio Travaglino and Antonio Raffone and Nicoletta D'Alessandris and Giulia Scaglione and Michele Valente and Giordana Tinnirello and Stefania Sfregola and {Padial Urtueta}, Belen and Angelo Piermattei and Federica Cianfrini and Antonino Mul{\`e} and Emma Bragantini and Zannoni, {Gian Franco}",

year = "2024",

doi = "10.3390/ijms25021056",

language = "English",

volume = "25",

pages = "1056--1062",

journal = "International Journal of Molecular Sciences",

issn = "1422-0067",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

}

Addante, F, D’Amati, A, Santoro, A, Angelico, G, Inzani, F, Arciuolo, D, Travaglino, A, Raffone, A, D'Alessandris, N, Scaglione, G, Valente, M, Tinnirello, G, Sfregola, S, Padial Urtueta, B, Piermattei, A, Cianfrini, F, Mulè, A, Bragantini, E & Zannoni, GF 2024, 'Mismatch Repair Deficiency as a Predictive and Prognostic Biomarker in Endometrial Cancer: A Review on Immunohistochemistry Staining Patterns and Clinical Implications', International Journal of Molecular Sciences, vol. 25, pagg. 1056-1062. https://doi.org/10.3390/ijms25021056

Mismatch Repair Deficiency as a Predictive and Prognostic Biomarker in Endometrial Cancer: A Review on Immunohistochemistry Staining Patterns and Clinical Implications. / Addante, Francesca; D’Amati, Antonio; Santoro, Angela et al.
In: International Journal of Molecular Sciences, Vol. 25, 2024, pag. 1056-1062.

Risultato della ricerca: Contributo in rivista › Articolo in rivista

TY - JOUR

T1 - Mismatch Repair Deficiency as a Predictive and Prognostic Biomarker in Endometrial Cancer: A Review on Immunohistochemistry Staining Patterns and Clinical Implications

AU - Addante, Francesca

AU - D’Amati, Antonio

AU - Santoro, Angela

AU - Angelico, Giuseppe

AU - Inzani, Frediano

AU - Arciuolo, Damiano

AU - Travaglino, Antonio

AU - Raffone, Antonio

AU - D'Alessandris, Nicoletta

AU - Scaglione, Giulia

AU - Valente, Michele

AU - Tinnirello, Giordana

AU - Sfregola, Stefania

AU - Padial Urtueta, Belen

AU - Piermattei, Angelo

AU - Cianfrini, Federica

AU - Mulè, Antonino

AU - Bragantini, Emma

AU - Zannoni, Gian Franco

PY - 2024

Y1 - 2024

N2 - Among the four endometrial cancer (EC) TCGA molecular groups, the MSI/hypermutated group represents an important percentage of tumors (30%), including different histotypes, and generally confers an intermediate prognosis for affected women, also providing new immunotherapeutic strategies. Immunohistochemistry for MMR proteins (MLH1, MSH2, MSH6 and PMS2) has become the optimal diagnostic MSI surrogate worldwide. This review aims to provide state-of-the-art knowledge on MMR deficiency/MSI in EC and to clarify the pathological assessment, interpretation pitfalls and reporting of MMR status.

AB - Among the four endometrial cancer (EC) TCGA molecular groups, the MSI/hypermutated group represents an important percentage of tumors (30%), including different histotypes, and generally confers an intermediate prognosis for affected women, also providing new immunotherapeutic strategies. Immunohistochemistry for MMR proteins (MLH1, MSH2, MSH6 and PMS2) has become the optimal diagnostic MSI surrogate worldwide. This review aims to provide state-of-the-art knowledge on MMR deficiency/MSI in EC and to clarify the pathological assessment, interpretation pitfalls and reporting of MMR status.

KW - ENDOMETRIAL CANCER

UR - http://hdl.handle.net/10807/271422

U2 - 10.3390/ijms25021056

DO - 10.3390/ijms25021056

M3 - Article

SN - 1422-0067

VL - 25

SP - 1056

EP - 1062

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

ER -

Mismatch Repair Deficiency as a Predictive and Prognostic Biomarker in Endometrial Cancer: A Review on Immunohistochemistry Staining Patterns and Clinical Implications

Abstract

Keywords

OSS delle Nazioni Unite

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