Minimally invasive versus standard laparotomic interval debulking surgery in ovarian neoplasm: A single-institution retrospective case-control study

Giovanni Scambia, Anna Fagotti, Salvatore Gueli Alletti, Marco Petrillo, Giuseppe Vizzielli, Carolina Bottoni, Federica Nardelli, Barbara Costantini, Lorena Quagliozzi, Valerio Gallotta

Risultato della ricerca: Contributo in rivistaArticolo in rivista

19 Citazioni (Scopus)

Abstract

Objective To further investigate the role of MIS comparing patients submitted to MI-IDS with a balanced population treated by standard laparotomy. Methods The investigational arm (Cases) includes 30 AEOC patients treated with MI-IDS. The Control arm included a consecutive series of 65 AEOC patients submitted to laparotomic IDS. Inclusion criteria were: age > 18 years, histologically proven EOC, clinical complete/partial response after NACT, and ECOG PS < 2. Preoperative clinical data, perioperative and oncological outcomes were analyzed. General Well-Being Schedule (GWBS) was administered to evaluate quality of life before and after surgery. Results Both groups were well-balanced. A higher percentage of women among Cases received bevacizumab-containing NACT compared with Controls. No statistical differences were registered in terms of surgical procedures and residual tumor. A significantly longer median OT in Cases was counterbalanced by more favorable EBL and median length of stay and TTC. No statistically significant differences were registered in terms of postoperative complications. Cases showed a 6 months longer PFS compared to Controls. However, in multivariate analysis only the administration of Bevacizumab and a shorter TTC were independently associated with a longer PFS. Regarding QoL, no statistically significant differences were registered in Cases between pre- and postoperative GWBS score. Differently from Controls where this difference was statistically significant and a more intense distress were recorded. Conclusions Minimally invasive approach could represent an advantageous alternative surgical way to perform interval debulking surgery in this specific subset of patients, with no impact on PFS. Based on these findings a randomized clinical trial is now under evaluation in our Institution.
Lingua originaleEnglish
pagine (da-a)516-520
Numero di pagine5
RivistaGynecologic Oncology
Volume143
DOI
Stato di pubblicazionePubblicato - 2016

Keywords

  • Interval debulking surgery
  • Laparoscopy
  • Minimally invasive
  • Obstetrics and Gynecology
  • Oncology
  • Ovarian cancer

Fingerprint Entra nei temi di ricerca di 'Minimally invasive versus standard laparotomic interval debulking surgery in ovarian neoplasm: A single-institution retrospective case-control study'. Insieme formano una fingerprint unica.

Cita questo