Migraine, arousal and sleep deprivation: comment on: "sleep quality, arousal and pain thresholds in migraineurs: a blinded controlled polysomnographic study"

Giacomo Della Marca, Catello Vollono, Elisa Testani, Anna Losurdo, Salvatore Mazza

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

1 Citazioni (Scopus)

Abstract

We discuss the hypothesis proposed by Engstrom and coworkers that Migraineurs have a relative sleep deprivation, which lowers the pain threshold and predispose to attacks. Previous data indicate that Migraineurs have a reduction of Cyclic Alternating Pattern (CAP), an essential mechanism of NREM sleep regulation which allows to dump the effect of incoming disruptive stimuli, and to protect sleep. The modifications of CAP observed in Migraineurs are similar to those observed in patients with impaired arousal (narcolepsy) and after sleep deprivation. The impairment of this mechanism makes Migraineurs more vulnerable to stimuli triggering attacks during sleep, and represents part of a more general vulnerability to incoming stimuli.
Lingua originaleEnglish
pagine (da-a)50-50
Numero di pagine1
RivistaTHE JOURNAL OF HEADACHE AND PAIN
Volume14
DOI
Stato di pubblicazionePubblicato - 2013

Keywords

  • Arousal
  • Cyclic alternating pattern
  • Migraine
  • Pain
  • Sleep
  • Sleep deprivation

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