MicroRNA as New Tools for Prostate Cancer Risk Assessment and Therapeutic Intervention: Results from Clinical Data Set and Patients' Samples

Ruggero De Maria Marchiano, Alessio Cannistraci, Anna Laura Di Pace, Désirée Bonci

Risultato della ricerca: Contributo in rivistaArticolo in rivista

37 Citazioni (Scopus)

Abstract

Prostate cancer (PCa) is one of the leading causes of cancer-related death in men. Despite considerable advances in prostate cancer early detection and clinical management, validation of new biomarkers able to predict the natural history of tumor progression is still necessary in order to reduce overtreatment and to guide therapeutic decisions. MicroRNAs are endogenous noncoding RNAs which offer a fast fine-tuning and energy-saving mechanism for posttranscriptional control of protein expression. Growing evidence indicate that these RNAs are able to regulate basic cell functions and their aberrant expression has been significantly correlated with cancer development. Therefore, detection of microRNAs in tumor tissues and body fluids represents a new tool for early diagnosis and patient prognosis prediction. In this review, we summarize current knowledge about microRNA deregulation in prostate cancer mainly focusing on the different clinical aspects of the disease. We also highlight the potential roles of microRNAs in PCa management, while also discussing several current challenges and needed future research.
Lingua originaleEnglish
pagine (da-a)146170-17
RivistaBioMed Research International
Volume2014
DOI
Stato di pubblicazionePubblicato - 2014

Keywords

  • Biochemistry, Genetics and Molecular Biology (all)
  • Databases, Genetic
  • Disease Progression
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Immunology and Microbiology (all)
  • Male
  • MicroRNAs
  • Prognosis
  • Prostatic Neoplasms
  • Risk Assessment

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