MicroRNA-155 influences B-cell function through PU.1 in rheumatoid arthritis

Elisa Gremese, Stefano Alivernini, Barbara Tolusso, Luca Petricca, Anna Laura Fedele, Clara Di Mario, Maria Rita Gigante, Gianfranco Ferraccioli, Mariola Kurowska-Stolarska, Aziza Elmesmari, Iain B. Mcinnes

Risultato della ricerca: Contributo in rivistaArticolo in rivista

63 Citazioni (Scopus)

Abstract

MicroRNA-155 (miR-155) is an important regulator of B cells in mice. B cells have a critical role in the pathogenesis of rheumatoid arthritis (RA). Here we show that miR-155 is highly expressed in peripheral blood B cells from RA patients compared with healthy individuals, particularly in the IgD - CD27 - memory B-cell population in ACPA + RA. MiR-155 is highly expressed in RA B cells from patients with synovial tissue containing ectopic germinal centres compared with diffuse synovial tissue. MiR-155 expression is associated reciprocally with lower expression of PU.1 at B-cell level in the synovial compartment. Stimulation of healthy donor B cells with CD40L, anti-IgM, IL-21, CpG, IFN-α, IL-6 or BAFF induces miR-155 and decreases PU.1 expression. Finally, inhibition of endogenous miR-155 in B cells of RA patients restores PU.1 and reduces production of antibodies. Our data suggest that miR-155 is an important regulator of B-cell activation in RA.
Lingua originaleEnglish
pagine (da-a)12970-N/A
RivistaNature Communications
Volume7
DOI
Stato di pubblicazionePubblicato - 2016

Keywords

  • Arthritis
  • B cells
  • Comorbidities
  • Diagnosis algorithm
  • Psoriasis
  • Psoriatic arthritis
  • Rheumatology
  • miRNA

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