MicroRNA-155-at the Critical Interface of Innate and Adaptive Immunity in Arthritis.

Stefano Alivernini, Elisa Gremese, Charles Mcsharry, Barbara Tolusso, Gianfranco Ferraccioli, Iain B. Mcinnes, Mariola Kurowska-Stolarska*

*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivistaArticolo in rivista

70 Citazioni (Scopus)


MicroRNAs (miRNAs) are small non-coding RNAs that fine-tune the cell response to a changing environment by modulating the cell transcriptome. miR-155 is a multifunctional miRNA enriched in cells of the immune system and is indispensable for the immune response. However, when deregulated, miR-155 contributes to the development of chronic inflammation, autoimmunity, cancer, and fibrosis. Herein, we review the evidence for the pathogenic role of miR-155 in driving aberrant activation of the immune system in rheumatoid arthritis, and its potential as a disease biomarker and therapeutic target.
Lingua originaleEnglish
pagine (da-a)1932-N/A
RivistaFrontiers in Immunology
Stato di pubblicazionePubblicato - 2018


  • microRNA


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