MicroRNA-155-at the Critical Interface of Innate and Adaptive Immunity in Arthritis.

Elisa Gremese, Stefano Alivernini, Barbara Tolusso, Gianfranco Ferraccioli, Charles Mcsharry, Iain B. Mcinnes, Mariola Kurowska-Stolarska

Risultato della ricerca: Contributo in rivistaArticolo in rivista

67 Citazioni (Scopus)

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs that fine-tune the cell response to a changing environment by modulating the cell transcriptome. miR-155 is a multifunctional miRNA enriched in cells of the immune system and is indispensable for the immune response. However, when deregulated, miR-155 contributes to the development of chronic inflammation, autoimmunity, cancer, and fibrosis. Herein, we review the evidence for the pathogenic role of miR-155 in driving aberrant activation of the immune system in rheumatoid arthritis, and its potential as a disease biomarker and therapeutic target.
Lingua originaleEnglish
pagine (da-a)1932-N/A
RivistaFrontiers in Immunology
DOI
Stato di pubblicazionePubblicato - 2018

Keywords

  • microRNA

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