MicroRNA-155-at the Critical Interface of Innate and Adaptive Immunity in Arthritis.

Stefano Alivernini; Elisa Gremese; Charles Mcsharry; Barbara Tolusso; Gianfranco Ferraccioli; Iain B. Mcinnes; Mariola Kurowska-Stolarska

doi:10.3389/fimmu.2017.01932

MicroRNA-155-at the Critical Interface of Innate and Adaptive Immunity in Arthritis.

Stefano Alivernini, Elisa Gremese, Charles Mcsharry, Barbara Tolusso, Gianfranco Ferraccioli, Iain B. Mcinnes, Mariola Kurowska-Stolarska^*

^*Autore corrispondente per questo lavoro

University of Glasgow

Risultato della ricerca: Contributo in rivista › Articolo in rivista

70 Citazioni (Scopus)

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs that fine-tune the cell response to a changing environment by modulating the cell transcriptome. miR-155 is a multifunctional miRNA enriched in cells of the immune system and is indispensable for the immune response. However, when deregulated, miR-155 contributes to the development of chronic inflammation, autoimmunity, cancer, and fibrosis. Herein, we review the evidence for the pathogenic role of miR-155 in driving aberrant activation of the immune system in rheumatoid arthritis, and its potential as a disease biomarker and therapeutic target.

Lingua originale	English
pagine (da-a)	1932-N/A
Rivista	Frontiers in Immunology
DOI	https://doi.org/10.3389/fimmu.2017.01932
Stato di pubblicazione	Pubblicato - 2018

Keywords

microRNA

OSS delle Nazioni Unite

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10.3389/fimmu.2017.01932

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abstract = "MicroRNAs (miRNAs) are small non-coding RNAs that fine-tune the cell response to a changing environment by modulating the cell transcriptome. miR-155 is a multifunctional miRNA enriched in cells of the immune system and is indispensable for the immune response. However, when deregulated, miR-155 contributes to the development of chronic inflammation, autoimmunity, cancer, and fibrosis. Herein, we review the evidence for the pathogenic role of miR-155 in driving aberrant activation of the immune system in rheumatoid arthritis, and its potential as a disease biomarker and therapeutic target.",

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AU - Alivernini, Stefano

AU - Gremese, Elisa

AU - Mcsharry, Charles

AU - Tolusso, Barbara

AU - Ferraccioli, Gianfranco

AU - Mcinnes, Iain B.

AU - Kurowska-Stolarska, Mariola

PY - 2018

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N2 - MicroRNAs (miRNAs) are small non-coding RNAs that fine-tune the cell response to a changing environment by modulating the cell transcriptome. miR-155 is a multifunctional miRNA enriched in cells of the immune system and is indispensable for the immune response. However, when deregulated, miR-155 contributes to the development of chronic inflammation, autoimmunity, cancer, and fibrosis. Herein, we review the evidence for the pathogenic role of miR-155 in driving aberrant activation of the immune system in rheumatoid arthritis, and its potential as a disease biomarker and therapeutic target.

AB - MicroRNAs (miRNAs) are small non-coding RNAs that fine-tune the cell response to a changing environment by modulating the cell transcriptome. miR-155 is a multifunctional miRNA enriched in cells of the immune system and is indispensable for the immune response. However, when deregulated, miR-155 contributes to the development of chronic inflammation, autoimmunity, cancer, and fibrosis. Herein, we review the evidence for the pathogenic role of miR-155 in driving aberrant activation of the immune system in rheumatoid arthritis, and its potential as a disease biomarker and therapeutic target.

KW - microRNA

UR - http://hdl.handle.net/10807/114714

U2 - 10.3389/fimmu.2017.01932

DO - 10.3389/fimmu.2017.01932

M3 - Article

SN - 1664-3224

SP - 1932-N/A

JO - Frontiers in Immunology

JF - Frontiers in Immunology

ER -

MicroRNA-155-at the Critical Interface of Innate and Adaptive Immunity in Arthritis.

Abstract

Keywords

OSS delle Nazioni Unite

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