Microparticles and microRNAs: new players in the complex field of coagulation

Luigi Marzio Biasucci, Claudia Camaioni, Massimo Gustapane, Pio Cialdella, Roberta Della Bona

Risultato della ricerca: Contributo in rivistaArticolo in rivista

20 Citazioni (Scopus)

Abstract

Atherosclerosis is a complex process that begins with endothelial dysfunction, and continues with several inflammatory processes leading, eventually, to plaque rupture and formation of arterial thrombus. Increased platelet reactivity and classical coagulation pathways are not the only players of the whole thrombotic process: microparticles (MPs), irregularly shaped small vesicles released from the plasma membrane after cell activation, apoptosis, or exposure to shear stress have been demonstrated to be involved in such a process. MicroRNAs (MiRs), small-non-coding single-strand RNAs acting as post-transcriptional modulator of target gene expression are expressed in the large majority of eukaryotes. MiRs are implicated in several phenomena: control of metabolism, control of cell-differentiation, control of cell-proliferation and control of cell-apoptosis, therefore contributing to physiologic and pathogenic processes in hematologic, genetic, infective and cardiac diseases. Microparticles operate as a delivery system of MiRs, playing an active and important role in processes such as coagulation and thrombosis. These novel findings also suggest MPs and, in particular MIRs, as possible and promising therapeutic targets.
Lingua originaleEnglish
pagine (da-a)291-296
Numero di pagine6
RivistaINTERNAL AND EMERGENCY MEDICINE
Volume8
DOI
Stato di pubblicazionePubblicato - 2013

Keywords

  • Apoptosis
  • Atherosclerosis
  • Blood Coagulation
  • Cell Membrane
  • Cell Proliferation
  • Cell-Derived Microparticles
  • Endothelial Cells
  • Endothelium, Vascular
  • Humans
  • MicroRNAs
  • Thrombosis

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