Microbiome: What intensivists should know

Giovanni Cammarota, Gianluca Ianiro, Radislav Nakov, Jonathan P. Segal

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

The standard conditions of critical illness (including sepsis, acute respiratory distress syndrome, and multiorgan failure) cause enormous global mortality and a growing economic burden. Increasing evidence suggests that critical illness may be associated with loss of commensal microbes and overgrowth of potentially pathogenic and inflammatory bacteria. This state could be associated with poor outcomes. Therefore, microbiota-targeted interventions are potentially attractive novel treatment options. Although the precise mechanisms of microbiome-directed treatments such as prebiotics, probiotics, and fecal microbiota transplantation remain to be determined, they can be utilized in the Intensive Care Unit (IC U) setting. The current review aims to offer intensivists an evidenced-based approach on what we currently know about the role of the microbiome in critical illness and how the microbiome could be targeted in the clinical practice to improve IC U-related outcomes.
Lingua originaleEnglish
pagine (da-a)777-785
Numero di pagine9
RivistaMINERVA ANESTESIOLOGICA
Volume86
DOI
Stato di pubblicazionePubblicato - 2020

Keywords

  • Gastrointestinal microbiome
  • Intensive Care Units
  • Microbiota
  • Critical Illness
  • Probiotics
  • Fecal Microbiota Transplantation
  • Humans
  • Dysbiosis

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