Methods in Molecular Biology

Silvia Masciarelli, Teresa Bellissimo, Ilaria Iosue, Francesco Fazi

Risultato della ricerca: Contributo in libroChapter

2 Citazioni (Scopus)

Abstract

Epigenetic mechanisms such as DNA methylation, posttranslational modifications of histone proteins, remodeling of nucleosomes, and the expression of noncoding RNAs contribute to the regulation of gene expression for the cell fate determination and tissue development. The disruption of these epigenetic mechanisms, in conjunction with genetic alterations, is a decisive element for cancer development and progression. The cancer phenotype is characterized by global DNA hypomethylation and gene-specific hypermethylation. The methylated DNA immunoprecipitation [MeDIP] is a useful approach currently used to clarify the functional consequences of DNA methylation on cell fate determination and cancer development.
Lingua originaleEnglish
Titolo della pubblicazione ospiteCancer Chemoprevention methods and protocols
Pagine69-76
Numero di pagine8
Volume1379
DOI
Stato di pubblicazionePubblicato - 2016

Serie di pubblicazioni

NomeMETHODS IN MOLECULAR BIOLOGY

Keywords

  • 5-Methyl-cytosine
  • Cancer chemoprevention
  • Carcinogenesis
  • Chromatin immunoprecipitation
  • CpG island
  • DNA
  • DNA Methylation
  • DNA methylation
  • Epigenesis, Genetic
  • Epigenetic remodeling
  • Humans
  • Immunoprecipitation
  • MeDIP
  • Neoplasms
  • Polymerase Chain Reaction

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