Abstract
Epigenetic mechanisms such as DNA methylation, posttranslational modifications of histone proteins, remodeling of nucleosomes, and the expression of noncoding RNAs contribute to the regulation of gene expression for the cell fate determination and tissue development. The disruption of these epigenetic mechanisms, in conjunction with genetic alterations, is a decisive element for cancer development and progression. The cancer phenotype is characterized by global DNA hypomethylation and gene-specific hypermethylation. The methylated DNA immunoprecipitation [MeDIP] is a useful approach currently used to clarify the functional consequences of DNA methylation on cell fate determination and cancer development.
| Lingua originale | English |
|---|---|
| Titolo della pubblicazione ospite | Cancer Chemoprevention methods and protocols |
| Pagine | 69-76 |
| Numero di pagine | 8 |
| Volume | 1379 |
| DOI | |
| Stato di pubblicazione | Pubblicato - 2016 |
Serie di pubblicazioni
| Nome | METHODS IN MOLECULAR BIOLOGY |
|---|
Keywords
- 5-Methyl-cytosine
- Cancer chemoprevention
- Carcinogenesis
- Chromatin immunoprecipitation
- CpG island
- DNA
- DNA Methylation
- DNA methylation
- Epigenesis, Genetic
- Epigenetic remodeling
- Humans
- Immunoprecipitation
- MeDIP
- Neoplasms
- Polymerase Chain Reaction
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