Methodological considerations for large-scale breath analysis studies: lessons from the U-BIOPRED severe asthma project

Paolo Montuschi, WM Ahmed, P Brinkman, H Weda, HH Knobel, Y Xu, TM Nijsen, R Goodacre, N Rattray, TJ Vink, M Santonico, G Pennazza, PJ Sterk, SJ Fowler

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

10 Citazioni (Scopus)

Abstract

Methods for breath sampling and analysis require robust quality assessment to minimise the risk of false discoveries. Planning large-scale multi-site breath metabolite profiling studies also requires careful consideration of systematic and random variation as a result of sampling and analysis techniques. In this study we use breath sample data from the recent U-BIOPRED cohort to evaluate and discuss some important methodological considerations such as batch variation and correction, variation between sites, storage and transportation, as well as inter-instrument analytical differences. Based on this we provide a summary of recommended best practices for new large scale multi-site studies
Lingua originaleEnglish
pagine (da-a)N/A-N/A
RivistaJournal of Breath Research
Volume13
DOI
Stato di pubblicazionePubblicato - 2019

Keywords

  • breath analysis
  • severe asthma

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