Metformin treatment does not affect total leptin levels and free leptin index in obese patients with polycystic ovary syndrome

Daniela Romualdi; Giuseppe Campagna; Luigi Selvaggi; R Cento; C Proto; Antonio Lanzone; Maurizio Guido

doi:10.1016/j.fertnstert.2007.05.004

Metformin treatment does not affect total leptin levels and free leptin index in obese patients with polycystic ovary syndrome

Daniela Romualdi, Giuseppe Campagna, Luigi Selvaggi, R Cento, C Proto, Antonio Lanzone, Maurizio Guido

Risultato della ricerca: Contributo in rivista › Articolo in rivista

19 Citazioni (Scopus)

Abstract

Leptin, particularly in its free form, is deeply involved in the regulation of energy balance. Insulin was suggested to influence plasmatic leptin levels and soluble leptin receptor in humans. However, this study indicates that metformin treatment, although improving insulin levels, does not exert a significant effect on either total leptin level or free leptin index in obese women with hyperinsulinemia and PCOS.

Lingua originale	English
pagine (da-a)	1273-1276
Numero di pagine	4
Rivista	Fertility and Sterility
Volume	89
DOI	https://doi.org/10.1016/j.fertnstert.2007.05.004
Stato di pubblicazione	Pubblicato - 2008

Keywords

Adult
Female
Humans
Hyperinsulinism
Hypoglycemic Agents
Insulin
Leptin
Metformin
Obesity
Polycystic Ovary Syndrome

OSS delle Nazioni Unite

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10.1016/j.fertnstert.2007.05.004

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abstract = "Leptin, particularly in its free form, is deeply involved in the regulation of energy balance. Insulin was suggested to influence plasmatic leptin levels and soluble leptin receptor in humans. However, this study indicates that metformin treatment, although improving insulin levels, does not exert a significant effect on either total leptin level or free leptin index in obese women with hyperinsulinemia and PCOS.",

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T1 - Metformin treatment does not affect total leptin levels and free leptin index in obese patients with polycystic ovary syndrome

AU - Romualdi, Daniela

AU - Campagna, Giuseppe

AU - Selvaggi, Luigi

AU - Cento, R

AU - Proto, C

AU - Lanzone, Antonio

AU - Guido, Maurizio

PY - 2008

Y1 - 2008

N2 - Leptin, particularly in its free form, is deeply involved in the regulation of energy balance. Insulin was suggested to influence plasmatic leptin levels and soluble leptin receptor in humans. However, this study indicates that metformin treatment, although improving insulin levels, does not exert a significant effect on either total leptin level or free leptin index in obese women with hyperinsulinemia and PCOS.

AB - Leptin, particularly in its free form, is deeply involved in the regulation of energy balance. Insulin was suggested to influence plasmatic leptin levels and soluble leptin receptor in humans. However, this study indicates that metformin treatment, although improving insulin levels, does not exert a significant effect on either total leptin level or free leptin index in obese women with hyperinsulinemia and PCOS.

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KW - Female

KW - Humans

KW - Hyperinsulinism

KW - Hypoglycemic Agents

KW - Insulin

KW - Leptin

KW - Metformin

KW - Obesity

KW - Polycystic Ovary Syndrome

KW - Adult

KW - Female

KW - Humans

KW - Hyperinsulinism

KW - Hypoglycemic Agents

KW - Insulin

KW - Leptin

KW - Metformin

KW - Obesity

KW - Polycystic Ovary Syndrome

UR - http://hdl.handle.net/10807/31762

U2 - 10.1016/j.fertnstert.2007.05.004

DO - 10.1016/j.fertnstert.2007.05.004

M3 - Article

SN - 0015-0282

VL - 89

SP - 1273

EP - 1276

JO - Fertility and Sterility

JF - Fertility and Sterility

ER -

Metformin treatment does not affect total leptin levels and free leptin index in obese patients with polycystic ovary syndrome

Abstract

Keywords

OSS delle Nazioni Unite

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