Metformin improves endothelial function in type 1 diabetic subjects: a pilot, placebo-controlled randomized study

Dario Pitocco; Francesco Zaccardi; Pierpaolo Tarzia; Maria Milo; Giuseppe Scavone; Paola Rizzo; Francesca Pagliaccia; Roberto Nerla; Antonino Di Franco; A. Manto; Bianca Rocca; Gaetano Antonio Lanza; Filippo Crea; Giovanni Ghirlanda

doi:10.1111/dom.12041

Metformin improves endothelial function in type 1 diabetic subjects: a pilot, placebo-controlled randomized study

Dario Pitocco, Francesco Zaccardi, Pierpaolo Tarzia, Maria Milo, Giuseppe Scavone, Paola Rizzo, Francesca Pagliaccia, Roberto Nerla, Antonino Di Franco, A. Manto, Bianca Rocca, Gaetano Antonio Lanza, Filippo Crea, Giovanni Ghirlanda

Risultato della ricerca: Contributo in rivista › Articolo in rivista

44 Citazioni (Scopus)

Abstract

Several studies have investigated the effects of metformin treatment in patients with type 1 diabetes mellitus (T1DM). No study has hitherto examined its effects on endothelial function in these patients. In this study we sought to evaluate the effect of metformin on endothelial function in type 1 diabetic patients.

Lingua originale	English
pagine (da-a)	427-431
Numero di pagine	5
Rivista	Diabetes, obesity & metabolism
Volume	15
DOI	https://doi.org/10.1111/dom.12041
Stato di pubblicazione	Pubblicato - 2013

Keywords

Adult
Biological Markers
Blood Glucose
Brachial Artery
Diabetes Mellitus, Type 1
Dinoprost
Double-Blind Method
Drug Therapy, Combination
Endothelium, Vascular
Female
Hemoglobin A, Glycosylated
Humans
Hypoglycemic Agents
Insulin
Male
Metformin
Oxidative Stress
Pilot Projects
Treatment Outcome
Vasodilation

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10.1111/dom.12041

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Pitocco, D., Zaccardi, F., Tarzia, P., Milo, M., Scavone, G., Rizzo, P., Pagliaccia, F., Nerla, R., Di Franco, A., Manto, A., Rocca, B., Lanza, G. A., Crea, F., & Ghirlanda, G. (2013). Metformin improves endothelial function in type 1 diabetic subjects: a pilot, placebo-controlled randomized study. Diabetes, obesity & metabolism, 15, 427-431. https://doi.org/10.1111/dom.12041

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title = "Metformin improves endothelial function in type 1 diabetic subjects: a pilot, placebo-controlled randomized study",

abstract = "Several studies have investigated the effects of metformin treatment in patients with type 1 diabetes mellitus (T1DM). No study has hitherto examined its effects on endothelial function in these patients. In this study we sought to evaluate the effect of metformin on endothelial function in type 1 diabetic patients.",

keywords = "Adult, Biological Markers, Blood Glucose, Brachial Artery, Diabetes Mellitus, Type 1, Dinoprost, Double-Blind Method, Drug Therapy, Combination, Endothelium, Vascular, Female, Hemoglobin A, Glycosylated, Humans, Hypoglycemic Agents, Insulin, Male, Metformin, Oxidative Stress, Pilot Projects, Treatment Outcome, Vasodilation, Adult, Biological Markers, Blood Glucose, Brachial Artery, Diabetes Mellitus, Type 1, Dinoprost, Double-Blind Method, Drug Therapy, Combination, Endothelium, Vascular, Female, Hemoglobin A, Glycosylated, Humans, Hypoglycemic Agents, Insulin, Male, Metformin, Oxidative Stress, Pilot Projects, Treatment Outcome, Vasodilation",

author = "Dario Pitocco and Francesco Zaccardi and Pierpaolo Tarzia and Maria Milo and Giuseppe Scavone and Paola Rizzo and Francesca Pagliaccia and Roberto Nerla and {Di Franco}, Antonino and A. Manto and Bianca Rocca and Lanza, {Gaetano Antonio} and Filippo Crea and Giovanni Ghirlanda",

year = "2013",

doi = "10.1111/dom.12041",

language = "English",

volume = "15",

pages = "427--431",

journal = "Diabetes, obesity & metabolism",

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Pitocco, D, Zaccardi, F, Tarzia, P, Milo, M, Scavone, G, Rizzo, P, Pagliaccia, F, Nerla, R, Di Franco, A, Manto, A, Rocca, B , Lanza, GA , Crea, F & Ghirlanda, G 2013, 'Metformin improves endothelial function in type 1 diabetic subjects: a pilot, placebo-controlled randomized study', Diabetes, obesity & metabolism, vol. 15, pagg. 427-431. https://doi.org/10.1111/dom.12041

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T1 - Metformin improves endothelial function in type 1 diabetic subjects: a pilot, placebo-controlled randomized study

AU - Pitocco, Dario

AU - Zaccardi, Francesco

AU - Tarzia, Pierpaolo

AU - Milo, Maria

AU - Scavone, Giuseppe

AU - Rizzo, Paola

AU - Pagliaccia, Francesca

AU - Nerla, Roberto

AU - Di Franco, Antonino

AU - Manto, A.

AU - Rocca, Bianca

AU - Lanza, Gaetano Antonio

AU - Crea, Filippo

AU - Ghirlanda, Giovanni

PY - 2013

Y1 - 2013

N2 - Several studies have investigated the effects of metformin treatment in patients with type 1 diabetes mellitus (T1DM). No study has hitherto examined its effects on endothelial function in these patients. In this study we sought to evaluate the effect of metformin on endothelial function in type 1 diabetic patients.

AB - Several studies have investigated the effects of metformin treatment in patients with type 1 diabetes mellitus (T1DM). No study has hitherto examined its effects on endothelial function in these patients. In this study we sought to evaluate the effect of metformin on endothelial function in type 1 diabetic patients.

KW - Adult

KW - Biological Markers

KW - Blood Glucose

KW - Brachial Artery

KW - Diabetes Mellitus, Type 1

KW - Dinoprost

KW - Double-Blind Method

KW - Drug Therapy, Combination

KW - Endothelium, Vascular

KW - Female

KW - Hemoglobin A, Glycosylated

KW - Humans

KW - Hypoglycemic Agents

KW - Insulin

KW - Male

KW - Metformin

KW - Oxidative Stress

KW - Pilot Projects

KW - Treatment Outcome

KW - Vasodilation

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KW - Biological Markers

KW - Blood Glucose

KW - Brachial Artery

KW - Diabetes Mellitus, Type 1

KW - Dinoprost

KW - Double-Blind Method

KW - Drug Therapy, Combination

KW - Endothelium, Vascular

KW - Female

KW - Hemoglobin A, Glycosylated

KW - Humans

KW - Hypoglycemic Agents

KW - Insulin

KW - Male

KW - Metformin

KW - Oxidative Stress

KW - Pilot Projects

KW - Treatment Outcome

KW - Vasodilation

UR - http://hdl.handle.net/10807/53549

U2 - 10.1111/dom.12041

DO - 10.1111/dom.12041

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EP - 431

JO - Diabetes, obesity & metabolism

JF - Diabetes, obesity & metabolism

ER -

Metformin improves endothelial function in type 1 diabetic subjects: a pilot, placebo-controlled randomized study

Abstract

Keywords

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