Metastatic medulloblastoma in 10-year-old girl treated successfully with chemotherapy without radiotherapy

A Schiavetti, G Varrasso, Palma Maurizi, G Trasimeni, C Carapella, M A Castello

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We report a case of high risk medulloblastoma with leptomeningeal intracranial and spinal metastasis in a 10-year-old girl treated successfully with conventional prolonged chemotherapy without radiotherapy. This is a particular case of medulloblastoma that at onset did not receive standard therapy for medulloblastoma i.e. neither surgery nor craniospinal irradiation. This 10-year-old Chinese girl affected with localized medulloblastoma was previously treated at a medical department in China only with radiotherapy on the posterior fossa. When the child arrived in Italy with progressed metastatic medulloblastoma, she was treated with carboplatin/etoposide association i.v. followed by oral etoposide and partial surgery of the primitive mass. The schedule of chemotherapy was etoposide 300 mg/sqm followed by carboplatin 1000 mg/sqm in one day every 21-28 days for the first six courses, then etoposide 200 mg/sqm and carboplatin 600 mg/sqm in one day every 28-35 days for further 11 courses and oral etoposide 50 mg/sqm/day for ten consecutive days and one week interval between two cycles for one year. At present the girl is alive and disease-free, and has been off-therapy for 31 months. Interestingly, in this case a long-lasting complete remission was obtained without radiotherapy and without myeloablative chemotherapy. Oral etoposide played an important role in achieving a complete remission
Lingua originaleEnglish
pagine (da-a)55-60
Numero di pagine6
RivistaJournal of Neuro-Oncology
Stato di pubblicazionePubblicato - 1999


  • Administration, Oral
  • Antineoplastic Agents
  • Antineoplastic Agents, Phytogenic
  • Antineoplastic Combined Chemotherapy Protocols
  • Carboplatin
  • Cerebellar Neoplasms
  • Child
  • Combined Modality Therapy
  • Drug Administration Schedule
  • Etoposide
  • Female
  • Humans
  • Injections, Intravenous
  • Magnetic Resonance Imaging
  • Medulloblastoma


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