Metabolic endotoxemia and saturated fat contribute to circulating NGAL concentrations in subjects with insulin resistance

J. M. Moreno-Navarrete; M. Manco; Melania Manco; J. Ibá̃Ez; E. García-Fuentes; F. Ortega; E. Gorostiaga; J. Vendrell; M. Izquierdo; C. Martínez; G. Nolfe; W. Ricart; Geltrude Mingrone; F. Tinahones; J. M. Fernández-Real

doi:10.1038/ijo.2009.242

Metabolic endotoxemia and saturated fat contribute to circulating NGAL concentrations in subjects with insulin resistance

J. M. Moreno-Navarrete, M. Manco, Melania Manco, J. Ibá̃Ez, E. García-Fuentes, F. Ortega, E. Gorostiaga, J. Vendrell, M. Izquierdo, C. Martínez, G. Nolfe, W. Ricart, Geltrude Mingrone, F. Tinahones, J. M. Fernández-Real

Risultato della ricerca: Contributo in rivista › Articolo in rivista

73 Citazioni (Scopus)

Abstract

Lipocalin-2 (neutrophil gelatinase-associated lipocalin, NGAL) is an innate immune system protein that has been linked to insulin resistance and obesity, but the mechanisms behind these associations are poorly known. We hypothesized that endotoxin (lipopolysaccharide, LPS) and fat intake were in the background of these associations.Design:We studied four cohorts: (1) a cross-sectional study in 194 subjects; (2) the changes in NGAL concentration induced by diet and weight loss in 36 obese women (with circadian rhythm in 8 of them); (3) the effects of acute fat intake on circulating NGAL concentration in 42 morbidly obese subjects; and (4) LPS-induced NGAL secretion ex vivo (whole blood and adipose tissue explants).

Lingua originale	English
pagine (da-a)	240-249
Numero di pagine	10
Rivista	International Journal of Obesity
Volume	34
DOI	https://doi.org/10.1038/ijo.2009.242
Stato di pubblicazione	Pubblicato - 2010

Keywords

Acute-Phase Proteins
Adipose Tissue
Adult
Body Mass Index
Carrier Proteins
Cross-Sectional Studies
Diabetes Mellitus, Type 2
Dietary Fats
Endotoxemia
Fasting
Female
Humans
Hyperlipidemias
Insulin Resistance
Lipocalins
Male
Membrane Glycoproteins
Middle Aged
Obesity, Morbid
Proto-Oncogene Proteins
Triglycerides
Weight Loss

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Moreno-Navarrete, J. M., Manco, M., Manco, M., Ibá̃Ez, J., García-Fuentes, E., Ortega, F., Gorostiaga, E., Vendrell, J., Izquierdo, M., Martínez, C., Nolfe, G., Ricart, W., Mingrone, G., Tinahones, F., & Fernández-Real, J. M. (2010). Metabolic endotoxemia and saturated fat contribute to circulating NGAL concentrations in subjects with insulin resistance. International Journal of Obesity, 34, 240-249. https://doi.org/10.1038/ijo.2009.242

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abstract = "Lipocalin-2 (neutrophil gelatinase-associated lipocalin, NGAL) is an innate immune system protein that has been linked to insulin resistance and obesity, but the mechanisms behind these associations are poorly known. We hypothesized that endotoxin (lipopolysaccharide, LPS) and fat intake were in the background of these associations.Design:We studied four cohorts: (1) a cross-sectional study in 194 subjects; (2) the changes in NGAL concentration induced by diet and weight loss in 36 obese women (with circadian rhythm in 8 of them); (3) the effects of acute fat intake on circulating NGAL concentration in 42 morbidly obese subjects; and (4) LPS-induced NGAL secretion ex vivo (whole blood and adipose tissue explants).",

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author = "Moreno-Navarrete, {J. M.} and M. Manco and Melania Manco and J. Ib{\'a}̃Ez and E. Garc{\'i}a-Fuentes and F. Ortega and E. Gorostiaga and J. Vendrell and M. Izquierdo and C. Mart{\'i}nez and G. Nolfe and W. Ricart and Geltrude Mingrone and F. Tinahones and Fern{\'a}ndez-Real, {J. M.}",

year = "2010",

doi = "10.1038/ijo.2009.242",

language = "English",

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pages = "240--249",

journal = "International Journal of Obesity",

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Moreno-Navarrete, JM, Manco, M, Manco, M, Ibá̃Ez, J, García-Fuentes, E, Ortega, F, Gorostiaga, E, Vendrell, J, Izquierdo, M, Martínez, C, Nolfe, G, Ricart, W, Mingrone, G, Tinahones, F & Fernández-Real, JM 2010, 'Metabolic endotoxemia and saturated fat contribute to circulating NGAL concentrations in subjects with insulin resistance', International Journal of Obesity, vol. 34, pagg. 240-249. https://doi.org/10.1038/ijo.2009.242

TY - JOUR

T1 - Metabolic endotoxemia and saturated fat contribute to circulating NGAL concentrations in subjects with insulin resistance

AU - Moreno-Navarrete, J. M.

AU - Manco, M.

AU - Manco, Melania

AU - Ibá̃Ez, J.

AU - García-Fuentes, E.

AU - Ortega, F.

AU - Gorostiaga, E.

AU - Vendrell, J.

AU - Izquierdo, M.

AU - Martínez, C.

AU - Nolfe, G.

AU - Ricart, W.

AU - Mingrone, Geltrude

AU - Tinahones, F.

AU - Fernández-Real, J. M.

PY - 2010

Y1 - 2010

N2 - Lipocalin-2 (neutrophil gelatinase-associated lipocalin, NGAL) is an innate immune system protein that has been linked to insulin resistance and obesity, but the mechanisms behind these associations are poorly known. We hypothesized that endotoxin (lipopolysaccharide, LPS) and fat intake were in the background of these associations.Design:We studied four cohorts: (1) a cross-sectional study in 194 subjects; (2) the changes in NGAL concentration induced by diet and weight loss in 36 obese women (with circadian rhythm in 8 of them); (3) the effects of acute fat intake on circulating NGAL concentration in 42 morbidly obese subjects; and (4) LPS-induced NGAL secretion ex vivo (whole blood and adipose tissue explants).

AB - Lipocalin-2 (neutrophil gelatinase-associated lipocalin, NGAL) is an innate immune system protein that has been linked to insulin resistance and obesity, but the mechanisms behind these associations are poorly known. We hypothesized that endotoxin (lipopolysaccharide, LPS) and fat intake were in the background of these associations.Design:We studied four cohorts: (1) a cross-sectional study in 194 subjects; (2) the changes in NGAL concentration induced by diet and weight loss in 36 obese women (with circadian rhythm in 8 of them); (3) the effects of acute fat intake on circulating NGAL concentration in 42 morbidly obese subjects; and (4) LPS-induced NGAL secretion ex vivo (whole blood and adipose tissue explants).

KW - Acute-Phase Proteins

KW - Adipose Tissue

KW - Adult

KW - Body Mass Index

KW - Carrier Proteins

KW - Cross-Sectional Studies

KW - Diabetes Mellitus, Type 2

KW - Dietary Fats

KW - Endotoxemia

KW - Fasting

KW - Female

KW - Humans

KW - Hyperlipidemias

KW - Insulin Resistance

KW - Lipocalins

KW - Male

KW - Membrane Glycoproteins

KW - Middle Aged

KW - Obesity, Morbid

KW - Proto-Oncogene Proteins

KW - Triglycerides

KW - Weight Loss

KW - Acute-Phase Proteins

KW - Adipose Tissue

KW - Adult

KW - Body Mass Index

KW - Carrier Proteins

KW - Cross-Sectional Studies

KW - Diabetes Mellitus, Type 2

KW - Dietary Fats

KW - Endotoxemia

KW - Fasting

KW - Female

KW - Humans

KW - Hyperlipidemias

KW - Insulin Resistance

KW - Lipocalins

KW - Male

KW - Membrane Glycoproteins

KW - Middle Aged

KW - Obesity, Morbid

KW - Proto-Oncogene Proteins

KW - Triglycerides

KW - Weight Loss

UR - http://hdl.handle.net/10807/7169

U2 - 10.1038/ijo.2009.242

DO - 10.1038/ijo.2009.242

M3 - Article

SN - 0307-0565

VL - 34

SP - 240

EP - 249

JO - International Journal of Obesity

JF - International Journal of Obesity

ER -

Metabolic endotoxemia and saturated fat contribute to circulating NGAL concentrations in subjects with insulin resistance

Abstract

Keywords

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