Metabolic endotoxemia and saturated fat contribute to circulating NGAL concentrations in subjects with insulin resistance

Geltrude Mingrone, Melania Manco, J. M. Moreno-Navarrete, M. Manco, J. Ibá̃Ez, E. García-Fuentes, F. Ortega, E. Gorostiaga, J. Vendrell, M. Izquierdo, C. Martínez, G. Nolfe, W. Ricart, F. Tinahones, J. M. Fernández-Real

Risultato della ricerca: Contributo in rivistaArticolo in rivista

73 Citazioni (Scopus)

Abstract

Lipocalin-2 (neutrophil gelatinase-associated lipocalin, NGAL) is an innate immune system protein that has been linked to insulin resistance and obesity, but the mechanisms behind these associations are poorly known. We hypothesized that endotoxin (lipopolysaccharide, LPS) and fat intake were in the background of these associations.Design:We studied four cohorts: (1) a cross-sectional study in 194 subjects; (2) the changes in NGAL concentration induced by diet and weight loss in 36 obese women (with circadian rhythm in 8 of them); (3) the effects of acute fat intake on circulating NGAL concentration in 42 morbidly obese subjects; and (4) LPS-induced NGAL secretion ex vivo (whole blood and adipose tissue explants).
Lingua originaleEnglish
pagine (da-a)240-249
Numero di pagine10
RivistaInternational Journal of Obesity
Volume34
DOI
Stato di pubblicazionePubblicato - 2010

Keywords

  • Acute-Phase Proteins
  • Adipose Tissue
  • Adult
  • Body Mass Index
  • Carrier Proteins
  • Cross-Sectional Studies
  • Diabetes Mellitus, Type 2
  • Dietary Fats
  • Endotoxemia
  • Fasting
  • Female
  • Humans
  • Hyperlipidemias
  • Insulin Resistance
  • Lipocalins
  • Male
  • Membrane Glycoproteins
  • Middle Aged
  • Obesity, Morbid
  • Proto-Oncogene Proteins
  • Triglycerides
  • Weight Loss

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