Metabolic effects and disposition of sebacate, an alternate dicarboxylic fuel substrate

Geltrude Mingrone, Esmeralda Capristo, Andrea De Gaetano, Marco Castagneto, Av Greco, C Raguso, A Tataranni, E Finotti, Rm Tacchino

Risultato della ricerca: Contributo in rivistaArticolo in rivista

18 Citazioni (Scopus)

Abstract

Disodium sebacate is a 10-carbon-atom dicarboxylic acid, proposed as substrate for parenteral nutrition. We investigated its pharmacokinetic profile and thermogenic effect during a short-time infusion (5 h at 10 g/h) in 7 male volunteers. Sebacate in serum and urine was measured by high-performance liquid chromatography. A single-compartment model with two linear elimination routes was fitted. Metabolic measurements (VO2, VCO2, respiratory quotient, metabolic rate) were continuously performed for 8 h (5 h during and 3 h after the infusion) by a canopy indirect calorimeter. The apparent volume of distribution of sebacate was 8.39 +/- 0.69 liters, and the plasma fractional removal rate constant was 0.0086 +/- 0.00077 min-1. The average half-life and plasma clearance were 80.6 min and 72 ml/min, respectively. The increase in metabolic rate, the decrease in respiratory quotient and the changes in ketone body, glucagon and insulin levels during the infusion were not significant. 24-hour catecholamine excretion was within normal limits. Calories administered by sebacate seem to be available for utilization without relevant metabolic side effects.
Lingua originaleEnglish
pagine (da-a)1-11
Numero di pagine11
RivistaAnnals of Nutrition and Metabolism
Volume36
Stato di pubblicazionePubblicato - 1992

Keywords

  • Adult
  • Algorithms
  • Chromatography, High Pressure Liquid
  • Decanoic Acids
  • Dicarboxylic Acids
  • Energy Metabolism
  • Humans
  • Infusions, Intravenous
  • Male
  • Obesity

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