Mesonephric-Like Adenocarcinomas a Rare Tumor: The Importance of Diagnosis

Stefano Restaino, Giulia Pellecchia, Angelica Tulisso, Chiara Paglietti, Maria Orsaria, Claudia Andreetta, Elena Poletto, Martina Arcieri, Monica Della Martina, Anna Biasioli, Laura Mariuzzi, Lorenza Driul, Giovanni Scambia, Giuseppe Vizzielli

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Mesonephric-like adenocarcinomas (MLA) are rare neoplasms that arise in the uterine body and ovary and have been added to the World Health Organisation's recent 2020 classification of female genital cancers. The pathogenesis of MLA is unknown and it remains debated whether they represent mesonephric carcinomas (Wolffian) arising in the endometrium/ovary or endometrioid carcinomas (Mullerian) closely mimicking mesonephric carcinomas. Here we report the case of a 57-year-old woman with an initial misdiagnosis of endometrioid adenocarcinoma on diagnostic biopsy. The patient came to our clinical evaluation for the appearance of menometrorrhagia complicated by anemia for several months. Therefore, she underwent pelvic echo-flowmetry, with indication for diagnostic hysteroscopy with endometrial biopsy, which yielded a positive result for endometrioid endometrial adenocarcinoma. Following staging CT scan and targeted examinations on pulmonary findings, the patient underwent surgery with surprise of definitive diagnosis deponent for endometrial MLA. Our intention is to establish a brief review of the scientific evidence in the literature and the tools available for a correct histological diagnosis, in the light of the scant anatomopathological evidence. Our question gives rise to the motive for the publication: is immunohistochemistry the right way to resolve the diagnostic error at histology, which is usually the only source of diagnostic certainty? This case is intended to alert of diagnostic error that risked having the patient treated as a neoplasm with a favorable prognosis and low degree of aggressiveness instead of for a very aggressive and poor prognosis tumor such as MLA.
Lingua originaleEnglish
pagine (da-a)1-6
Numero di pagine6
RivistaInternational Journal of Environmental Research and Public Health
Volume19
DOI
Stato di pubblicazionePubblicato - 2022

Keywords

  • case report
  • the importance of diagnosis
  • mesonephric-like adenocarcinomas
  • confounding hystology

Fingerprint

Entra nei temi di ricerca di 'Mesonephric-Like Adenocarcinomas a Rare Tumor: The Importance of Diagnosis'. Insieme formano una fingerprint unica.

Cita questo