Abstract
Background: The aim of this retrospective study was to investigate the incidence of mesenteric lymph node (MLN) involvement, and its prognostic role in advanced ovarian cancer (OC). Methods: OC patients undergoing rectosigmoid resection during primary debulking surgery or interval debulking surgery were recorded. Progression-free survival (PFS) and overall survival were calculated from the date of diagnosis to the date of relapse/progression, death of disease, or the date of last follow-up. Results: MLNs were detected in 102/148 cases (68.9 %); the rate of MLN involvement was 47.0 %. The percentage of metastatic MLNs was higher in cases with >5 MLNs removed compared with cases with ≤5 MLNs removed (62.7 % vs. 31.3 %; p = 0.0027). A progressive increase in the rate of metastatic MLNs was documented in association with depth of bowel infiltration (p = 0.026). Cases with metastatic MLNs experienced isolated celiac trunk or aortic lymph node recurrences more frequently than patients without MLN involvement (44.8 % vs. 10.7 %; p = 0.0008). PFS did not differ between cases with positive versus negative MLN involvement (2-year PFS = 31 % vs. 43 %; p = 0.58). Conclusion: OC patients undergoing rectosigmoid resection showed metastatic MLN involvement in 47.0 % of cases. Metastatic MLN status is associated with a high rate of isolated aortic and celiac trunk lymph node recurrences. © 2014 Society of Surgical Oncology.
Lingua originale | English |
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pagine (da-a) | 2369-2375 |
Numero di pagine | 7 |
Rivista | Annals of Surgical Oncology |
Volume | 21 |
DOI | |
Stato di pubblicazione | Pubblicato - 2014 |
Keywords
- Adenocarcinoma, Clear Cell
- Adenocarcinoma, Mucinous
- Adult
- Aged
- Aged, 80 and over
- Cystadenocarcinoma, Serous
- Endometrial Neoplasms
- Female
- Follow-Up Studies
- Humans
- Lymph Node Excision
- Lymph Nodes
- Lymphatic Metastasis
- Mesentery
- Middle Aged
- Neoplasm Grading
- Oncology
- Ovarian Neoplasms
- Prognosis
- Rectum
- Retrospective Studies
- Sigmoid Neoplasms
- Surgery
- Survival Rate