Mesenchymal stem/stromal cells: a new ''cells as drugs'' paradigm. Efficacy and critical aspects in cell therapy

Giulio Alessandri; Franco Locatelli; Ornella Parolini

doi:10.2174/1381612811319130015

Mesenchymal stem/stromal cells: a new ''cells as drugs'' paradigm. Efficacy and critical aspects in cell therapy

Giulio Alessandri, Franco Locatelli, Ornella Parolini

Risultato della ricerca: Contributo in rivista › Articolo in rivista

118 Citazioni (SciVal)

Abstract

Mesenchymal stem cells (MSCs) were first isolated more than 50 years ago from the bone marrow. Currently MSCs may also be isolated from several alternative sources and they have been used in more than a hundred clinical trials worldwide to treat a wide variety of diseases. The MSCs mechanism of action is undefined and currently under investigation. For in vivo purposes MSCs must be produced in compliance with good manufacturing practices and this has stimulated research on MSCs characterization and safety. The objective of this review is to describe recent developments regarding MSCs properties, physiological effects, delivery, clinical applications and possible side effects.

Lingua originale	English
pagine (da-a)	2459-2473
Numero di pagine	15
Rivista	Current Pharmaceutical Design
Volume	19
DOI	https://doi.org/10.2174/1381612811319130015
Stato di pubblicazione	Pubblicato - 2013

Keywords

Cell- and Tissue-Based Therapy
Humans
Immunophenotyping
Mesenchymal Stromal Cells

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10.2174/1381612811319130015

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AU - Locatelli, Franco

AU - Parolini, Ornella

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KW - Immunophenotyping

KW - Mesenchymal Stromal Cells

KW - Cell- and Tissue-Based Therapy

KW - Humans

KW - Immunophenotyping

KW - Mesenchymal Stromal Cells

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ER -

Mesenchymal stem/stromal cells: a new ''cells as drugs'' paradigm. Efficacy and critical aspects in cell therapy

Abstract

Keywords

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