Mesenchymal stem cells for acute graft-versus-host disease/Authors' reply

Yuji Miura; Masahiro Kami; Masaharu Tsubokura; Naoko Takei; Tsunehiko Komatsu; K Le Blanc; W Fibbe; F Frassoni; Franco Locatelli; O Ringdén

doi:10.1016/S0140-6736(08)61300-8

Mesenchymal stem cells for acute graft-versus-host disease/Authors' reply

Yuji Miura
, Masahiro Kami
, Masaharu Tsubokura
, Naoko Takei
, Tsunehiko Komatsu
, K Le Blanc
, W Fibbe
, F Frassoni
, Franco Locatelli
, O Ringdén

Risultato della ricerca: Contributo in rivista › Articolo

Abstract

Besides the immune regulatory role of mesenchymal stem cells, in models of experimental injury, intravenous administration of these cells improves organ healing, mainly through paracrine effects and a shift from the production of proinflammatory to anti-inflammatory cytokines at the site of injury.2,3 Furthermore, we have previously shown that immune reconstitution improves after mesenchymal stem-cell infusion, with resolution of graft-versus-host disease and subsequent tapering of immunosuppressive drugs.4 However, we acknowledge that the present study is insufficiently powered to exclude an effect of mesenchymal stem cells on the rate of infections.

Lingua originale	Inglese
pagine (da-a)	716-N/A
Rivista	The Lancet
Volume	372
Numero di pubblicazione	9640
DOI	https://doi.org/10.1016/S0140-6736(08)61300-8
Stato di pubblicazione	Pubblicato - 2008

All Science Journal Classification (ASJC) codes

Medicina Generale

Keywords

N/A

Accesso al documento

10.1016/S0140-6736(08)61300-8

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AU - Miura, Yuji

AU - Kami, Masahiro

AU - Tsubokura, Masaharu

AU - Takei, Naoko

AU - Komatsu, Tsunehiko

AU - Le Blanc, K

AU - Fibbe, W

AU - Frassoni, F

AU - Locatelli, Franco

AU - Ringdén, O

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AB - Besides the immune regulatory role of mesenchymal stem cells, in models of experimental injury, intravenous administration of these cells improves organ healing, mainly through paracrine effects and a shift from the production of proinflammatory to anti-inflammatory cytokines at the site of injury.2,3 Furthermore, we have previously shown that immune reconstitution improves after mesenchymal stem-cell infusion, with resolution of graft-versus-host disease and subsequent tapering of immunosuppressive drugs.4 However, we acknowledge that the present study is insufficiently powered to exclude an effect of mesenchymal stem cells on the rate of infections.

KW - N/A

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ER -

Mesenchymal stem cells for acute graft-versus-host disease/Authors' reply

Abstract

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Keywords

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