Meropenem/ vaborbactam: a next generation β-lactam β-lactamase inhibitor combination

Mario Tumbarello, Paola Del Giacomo, Andrea Novelli, Gian Maria Rossolini

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Introduction: infections due to carbapenem-resistant Enterobacterales (CRE) constitute a worldwide threat and are associated with significant mortality, especially in fragile patients, and costs. Meropenem-vaborbactam (M/V) is a combination of a group 2 carbapenem with a novel cyclic boronic acid-based β-lactamase inhibitor which has shown good efficacy against KPC carbapenemase-producing Klebsiella pneumoniae, which are amongst the most prevalent types of CRE.Areas covered: This article reviews the microbiological and pharmacological profile and current clinical experience and safety of M/V in the treatment of infections caused by CRE.Expert opinion: M/V is a promising drug for the treatment of infections due to KPC-producing CRE (KPC-CRE). It exhibited an almost complete coverage of KPC-CRE isolates from large surveillance studies and a low propensity for resistance selection, retaining activity also against strains producing KPC mutants resistant to ceftazidime-avibactam. Both meropenem and vaborbactam have a favorable pharmacokinetic profile, with similar kinetic properties, a good intrapulmonary penetration and are efficiently cleared during continuous veno-venous hemofiltration (CVVH). According to available data, M/V monotherapy is associated with higher clinical cure rates and lower rates of adverse events, especially in terms of nephrotoxicity, if compared to "older" combination therapies.
Lingua originaleEnglish
pagine (da-a)N/A-N/A
RivistaExpert Review of Anti-Infective Therapy
DOI
Stato di pubblicazionePubblicato - 2020

Keywords

  • KPC carbapenemase
  • KPC-producing Klebsiella pneumoniae
  • carbapenem-resistant Enterobacterales (CRE)
  • meropenem-vaborbactam (M/V)

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