Mechanisms of Helicobacter pylori antibiotic resistance: An updated appraisal

Cesare Hassan, Vd Francesco, A Zullo, F Giorgio, R Rosania, E. Ierardi

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Helicobacter pylori (H. pylori) antibiotic resistance is the main factor affecting the efficacy of the current eradicating therapies. The aim of this editorial is to report on the recent information about the mechanisms accounting for the resistance to the different antibiotics currently utilized in H. pylori eradicating treatments. Different mechanisms of resistance to clarithromycin, metronidazole, quinolones, amoxicillin and tetracycline are accurately detailed (point mutations, redox intracellular potential, pump efflux systems, membrane permeability) on the basis of the most recent data available from the literature. The next hope for the future is that by improving the knowledge of resistance mechanisms, the elaboration of rational and efficacious associations for the treatment of the infection will be possible. Another auspicious progress might be the possibility of a cheap, feasible and reliable laboratory test to predict the outcome of a therapeutic scheme.
Lingua originaleEnglish
pagine (da-a)35-41
Numero di pagine7
RivistaWORLD JOURNAL OF GASTROINTESTINAL PATHOPHYSIOLOGY
Volume2
DOI
Stato di pubblicazionePubblicato - 2011
Pubblicato esternamenteYes

Keywords

  • Helicobacter pylori

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