TY - JOUR
T1 - Mechanisms in endocrinology: vitamin D as a potential contributor in endocrine health and disease.
AU - Muscogiuri, Giovanna
AU - Mitri, Joanna
AU - Mathieu, Chantal
AU - Badenhoop, Klaus
AU - Tamer, Gonca
AU - Orio, Francesco
AU - Mezza, Teresa
AU - Vieth, Reinhold
AU - Colao, Annamaria
AU - Pittas, Anastassios
PY - 2014
Y1 - 2014
N2 - Abstract
OBJECTIVE:
It has been suggested that vitamin D may play a role in the pathogenesis of several endocrine diseases, such as hyperparathyroidism, type 1 diabetes (T1DM), type 2 diabetes (T2DM), autoimmune thyroid diseases, Addison's disease and polycystic ovary syndrome (PCOS). In this review, we debate the role of vitamin D in the pathogenesis of endocrine diseases.
METHODS:
Narrative overview of the literature synthesizing the current evidence retrieved from searches of computerized databases, hand searches and authoritative texts.
RESULTS:
Evidence from basic science supports a role for vitamin D in many endocrine conditions. In humans, inverse relationships have been reported not only between blood 25-hydroxyvitamin D and parathyroid hormone concentrations but also with risk of T1DM, T2DM, and PCOS. There is less evidence for an association with Addison's disease or autoimmune thyroid disease. Vitamin D supplementation may have a role for prevention of T2DM, but the available evidence is not consistent.
CONCLUSIONS:
Although observational studies support a potential role of vitamin D in endocrine disease, high quality evidence from clinical trials does not exist to establish a place for vitamin D supplementation in optimizing endocrine health. Ongoing randomized controlled trials are expected to provide insights into the efficacy and safety of vitamin D in the management of endocrine disease.
© 2014 European Society of Endocrinology.
AB - Abstract
OBJECTIVE:
It has been suggested that vitamin D may play a role in the pathogenesis of several endocrine diseases, such as hyperparathyroidism, type 1 diabetes (T1DM), type 2 diabetes (T2DM), autoimmune thyroid diseases, Addison's disease and polycystic ovary syndrome (PCOS). In this review, we debate the role of vitamin D in the pathogenesis of endocrine diseases.
METHODS:
Narrative overview of the literature synthesizing the current evidence retrieved from searches of computerized databases, hand searches and authoritative texts.
RESULTS:
Evidence from basic science supports a role for vitamin D in many endocrine conditions. In humans, inverse relationships have been reported not only between blood 25-hydroxyvitamin D and parathyroid hormone concentrations but also with risk of T1DM, T2DM, and PCOS. There is less evidence for an association with Addison's disease or autoimmune thyroid disease. Vitamin D supplementation may have a role for prevention of T2DM, but the available evidence is not consistent.
CONCLUSIONS:
Although observational studies support a potential role of vitamin D in endocrine disease, high quality evidence from clinical trials does not exist to establish a place for vitamin D supplementation in optimizing endocrine health. Ongoing randomized controlled trials are expected to provide insights into the efficacy and safety of vitamin D in the management of endocrine disease.
© 2014 European Society of Endocrinology.
KW - vitamin d
KW - vitamin d
UR - http://hdl.handle.net/10807/147819
U2 - 10.1530/EJE-14-0158
DO - 10.1530/EJE-14-0158
M3 - Article
SN - 0804-4643
VL - 171
SP - 101
EP - 110
JO - European Journal of Endocrinology
JF - European Journal of Endocrinology
ER -