Mechanism of aluminium bio-mineralization in the apoferritin cavity

Michela Chiarpotto, Gabriele Ciasca, Massimo Vassalli, Cristina Rossi, Gaetano Campi, Alessandro Ricci, Bocca Beatrice, Anna Pino, Alimonti Alessandro, Pasquale De Sole, Massimiliano Papi*

*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivistaArticolopeer review

16 Citazioni (Scopus)

Abstract

Many experimental evidences point out the correlation between the presence of aluminum-ferritin\r\ncomplex and neursopathological disorders. In these complexes, two different ranges of Aluminium\r\n(Al) atoms are usually found, i.e., just few atoms or several hundreds. Here, we investigated the invitro\r\nAl-apoferritin binding, with the aim to elucidate the mechanism behind the formation of Alferritin\r\ncomplexes in-vivo. To this purpose, we studied the mineralization of Al in its ionic and\r\ncomplexed form with citrate demonstrating that high Al levels found in clinical studies can be\r\nobtained only conveying Al by small physiological ligands.
Lingua originaleInglese
pagine (da-a)1-5
Numero di pagine5
RivistaApplied Physics Letters
Volume2013
Numero di pubblicazione103
DOI
Stato di pubblicazionePubblicato - 2013

All Science Journal Classification (ASJC) codes

  • Fisica e Astronomia (varie)

Keywords

  • Aluminium bio-mineralization
  • Apoferritin

Fingerprint

Entra nei temi di ricerca di 'Mechanism of aluminium bio-mineralization in the apoferritin cavity'. Insieme formano una fingerprint unica.

Cita questo