Mechanism of aluminium bio-mineralization in the apoferritin cavity

Gabriele Ciasca, Massimiliano Papi, Michela Chiarpotto, Cristina Rossi, Pasquale De Sole, M. Vassalli, G. Campi, A. Ricci, B. Bocca, A. Pino, A. Alimonti

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

15 Citazioni (Scopus)

Abstract

Many experimental evidences point out the correlation between the presence of aluminum-ferritin complex and neursopathological disorders. In these complexes, two different ranges of Aluminium (Al) atoms are usually found, i.e., just few atoms or several hundreds. Here, we investigated the invitro Al-apoferritin binding, with the aim to elucidate the mechanism behind the formation of Alferritin complexes in-vivo. To this purpose, we studied the mineralization of Al in its ionic and complexed form with citrate demonstrating that high Al levels found in clinical studies can be obtained only conveying Al by small physiological ligands.
Lingua originaleEnglish
pagine (da-a)1-5
Numero di pagine5
RivistaApplied Physics Letters
Volume2013
DOI
Stato di pubblicazionePubblicato - 2013

Keywords

  • Aluminium bio-mineralization
  • Apoferritin

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