Mechanism of aluminium bio-mineralization in the apoferritin cavity

Gabriele Ciasca; Massimiliano Papi; Michela Chiarpotto; Cristina Rossi; Pasquale De Sole; M. Vassalli; G. Campi; A. Ricci; B. Bocca; A. Pino; A. Alimonti

doi:10.1063/1.4818749

Mechanism of aluminium bio-mineralization in the apoferritin cavity

Gabriele Ciasca, Massimiliano Papi, Michela Chiarpotto, Cristina Rossi, Pasquale De Sole, M. Vassalli, G. Campi, A. Ricci, B. Bocca, A. Pino, A. Alimonti

Risultato della ricerca: Contributo in rivista › Articolo in rivista › peer review

16 Citazioni (Scopus)

Abstract

Many experimental evidences point out the correlation between the presence of aluminum-ferritin complex and neursopathological disorders. In these complexes, two different ranges of Aluminium (Al) atoms are usually found, i.e., just few atoms or several hundreds. Here, we investigated the invitro Al-apoferritin binding, with the aim to elucidate the mechanism behind the formation of Alferritin complexes in-vivo. To this purpose, we studied the mineralization of Al in its ionic and complexed form with citrate demonstrating that high Al levels found in clinical studies can be obtained only conveying Al by small physiological ligands.

Lingua originale	English
pagine (da-a)	1-5
Numero di pagine	5
Rivista	Applied Physics Letters
Volume	2013
DOI	https://doi.org/10.1063/1.4818749
Stato di pubblicazione	Pubblicato - 2013

Keywords

Aluminium bio-mineralization
Apoferritin

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10.1063/1.4818749

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title = "Mechanism of aluminium bio-mineralization in the apoferritin cavity",

abstract = "Many experimental evidences point out the correlation between the presence of aluminum-ferritin complex and neursopathological disorders. In these complexes, two different ranges of Aluminium (Al) atoms are usually found, i.e., just few atoms or several hundreds. Here, we investigated the invitro Al-apoferritin binding, with the aim to elucidate the mechanism behind the formation of Alferritin complexes in-vivo. To this purpose, we studied the mineralization of Al in its ionic and complexed form with citrate demonstrating that high Al levels found in clinical studies can be obtained only conveying Al by small physiological ligands.",

keywords = "Aluminium bio-mineralization, Apoferritin, Aluminium bio-mineralization, Apoferritin",

author = "Gabriele Ciasca and Massimiliano Papi and Michela Chiarpotto and Cristina Rossi and {De Sole}, Pasquale and M. Vassalli and G. Campi and A. Ricci and B. Bocca and A. Pino and A. Alimonti",

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doi = "10.1063/1.4818749",

language = "English",

volume = "2013",

pages = "1--5",

journal = "Applied Physics Letters",

issn = "0003-6951",

publisher = "American Institute of Physics:2 Huntington Quadrangle, Suite 1NO1:Melville, NY 11747:(800)344-6902, (631)576-2287, EMAIL: subs@aip.org, INTERNET: http://www.aip.org, Fax: (516)349-9704",

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Mechanism of aluminium bio-mineralization in the apoferritin cavity. / Ciasca, Gabriele ; Papi, Massimiliano; Chiarpotto, Michela; Rossi, Cristina; De Sole, Pasquale; Vassalli, M.; Campi, G.; Ricci, A.; Bocca, B.; Pino, A.; Alimonti, A.

In: Applied Physics Letters, Vol. 2013, 2013, pag. 1-5.

Risultato della ricerca: Contributo in rivista › Articolo in rivista › peer review

TY - JOUR

T1 - Mechanism of aluminium bio-mineralization in the apoferritin cavity

AU - Ciasca, Gabriele

AU - Papi, Massimiliano

AU - Chiarpotto, Michela

AU - Rossi, Cristina

AU - De Sole, Pasquale

AU - Vassalli, M.

AU - Campi, G.

AU - Ricci, A.

AU - Bocca, B.

AU - Pino, A.

AU - Alimonti, A.

PY - 2013

Y1 - 2013

N2 - Many experimental evidences point out the correlation between the presence of aluminum-ferritin complex and neursopathological disorders. In these complexes, two different ranges of Aluminium (Al) atoms are usually found, i.e., just few atoms or several hundreds. Here, we investigated the invitro Al-apoferritin binding, with the aim to elucidate the mechanism behind the formation of Alferritin complexes in-vivo. To this purpose, we studied the mineralization of Al in its ionic and complexed form with citrate demonstrating that high Al levels found in clinical studies can be obtained only conveying Al by small physiological ligands.

AB - Many experimental evidences point out the correlation between the presence of aluminum-ferritin complex and neursopathological disorders. In these complexes, two different ranges of Aluminium (Al) atoms are usually found, i.e., just few atoms or several hundreds. Here, we investigated the invitro Al-apoferritin binding, with the aim to elucidate the mechanism behind the formation of Alferritin complexes in-vivo. To this purpose, we studied the mineralization of Al in its ionic and complexed form with citrate demonstrating that high Al levels found in clinical studies can be obtained only conveying Al by small physiological ligands.

KW - Aluminium bio-mineralization

KW - Apoferritin

KW - Aluminium bio-mineralization

KW - Apoferritin

UR - http://hdl.handle.net/10807/52060

U2 - 10.1063/1.4818749

DO - 10.1063/1.4818749

M3 - Article

VL - 2013

SP - 1

EP - 5

JO - Applied Physics Letters

JF - Applied Physics Letters

SN - 0003-6951

ER -

Mechanism of aluminium bio-mineralization in the apoferritin cavity

Abstract

Keywords

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