TY - JOUR
T1 - Mechanism of aluminium bio-mineralization in the apoferritin cavity
AU - Chiarpotto, Michela
AU - Ciasca, Gabriele
AU - Vassalli, Massimo
AU - Rossi, Cristina
AU - Campi, Gaetano
AU - Ricci, Alessandro
AU - Beatrice, Bocca
AU - Pino, Anna
AU - Alessandro, Alimonti
AU - De Sole, Pasquale
AU - Papi, Massimiliano
PY - 2013
Y1 - 2013
N2 - Many experimental evidences point out the correlation between the presence of aluminum-ferritin\r\ncomplex and neursopathological disorders. In these complexes, two different ranges of Aluminium\r\n(Al) atoms are usually found, i.e., just few atoms or several hundreds. Here, we investigated the invitro\r\nAl-apoferritin binding, with the aim to elucidate the mechanism behind the formation of Alferritin\r\ncomplexes in-vivo. To this purpose, we studied the mineralization of Al in its ionic and\r\ncomplexed form with citrate demonstrating that high Al levels found in clinical studies can be\r\nobtained only conveying Al by small physiological ligands.
AB - Many experimental evidences point out the correlation between the presence of aluminum-ferritin\r\ncomplex and neursopathological disorders. In these complexes, two different ranges of Aluminium\r\n(Al) atoms are usually found, i.e., just few atoms or several hundreds. Here, we investigated the invitro\r\nAl-apoferritin binding, with the aim to elucidate the mechanism behind the formation of Alferritin\r\ncomplexes in-vivo. To this purpose, we studied the mineralization of Al in its ionic and\r\ncomplexed form with citrate demonstrating that high Al levels found in clinical studies can be\r\nobtained only conveying Al by small physiological ligands.
KW - Aluminium bio-mineralization
KW - Apoferritin
KW - Aluminium bio-mineralization
KW - Apoferritin
UR - https://publicatt.unicatt.it/handle/10807/52060
UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84883346918&origin=inward
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84883346918&origin=inward
U2 - 10.1063/1.4818749
DO - 10.1063/1.4818749
M3 - Article
SN - 0003-6951
VL - 2013
SP - 1
EP - 5
JO - Applied Physics Letters
JF - Applied Physics Letters
IS - 103
ER -