Measuring Fatigue and Fatigability in Spinal Muscular Atrophy (SMA): Challenges and Opportunities

Rafael S. Rodriguez-Torres; David Uher; Emma L. Gay; Giorgia Coratti; Sally Dunaway Young; Annemarie Rohwer; Robert Muni Lofra; Darryl C. De Vivo; Michio Hirano; Nancy W. Glynn; Jacqueline Montes

doi:10.3390/jcm12103458

Measuring Fatigue and Fatigability in Spinal Muscular Atrophy (SMA): Challenges and Opportunities

Rafael S. Rodriguez-Torres, David Uher, Emma L. Gay, Giorgia Coratti, Sally Dunaway Young, Annemarie Rohwer, Robert Muni Lofra, Darryl C. De Vivo, Michio Hirano, Nancy W. Glynn, Jacqueline Montes

Risultato della ricerca: Contributo in rivista › Articolo in rivista

Abstract

Fatigue, a common symptom, together with the characteristic of performance fatigability, are well-documented features of SMA that impact quality of life and function. Importantly, establishing associations between multidimensional self-reported fatigue scales and patient performance has proven difficult. This review was conducted to evaluate the various patient-reported fatigue scales applied in SMA, with the objective of considering the limitations and advantages of each measure. Variable use of fatigue-related nomenclature, including conflicting terminology interpretation, has affected assessment of physical fatigue attributes, specifically perceived fatigability. This review encourages the development of original patient-reported scales to enable perceived fatigability assessment, providing a potential complementary method of evaluating treatment response.

Lingua originale	English
pagine (da-a)	N/A-N/A
Rivista	Journal of Clinical Medicine
Volume	12
DOI	https://doi.org/10.3390/jcm12103458
Stato di pubblicazione	Pubblicato - 2023

Keywords

SPINAL MUSCULAR ATROPHY

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10.3390/jcm12103458

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abstract = "Fatigue, a common symptom, together with the characteristic of performance fatigability, are well-documented features of SMA that impact quality of life and function. Importantly, establishing associations between multidimensional self-reported fatigue scales and patient performance has proven difficult. This review was conducted to evaluate the various patient-reported fatigue scales applied in SMA, with the objective of considering the limitations and advantages of each measure. Variable use of fatigue-related nomenclature, including conflicting terminology interpretation, has affected assessment of physical fatigue attributes, specifically perceived fatigability. This review encourages the development of original patient-reported scales to enable perceived fatigability assessment, providing a potential complementary method of evaluating treatment response.",

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T1 - Measuring Fatigue and Fatigability in Spinal Muscular Atrophy (SMA): Challenges and Opportunities

AU - Rodriguez-Torres, Rafael S.

AU - Uher, David

AU - Gay, Emma L.

AU - Coratti, Giorgia

AU - Dunaway Young, Sally

AU - Rohwer, Annemarie

AU - Muni Lofra, Robert

AU - De Vivo, Darryl C.

AU - Hirano, Michio

AU - Glynn, Nancy W.

AU - Montes, Jacqueline

PY - 2023

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N2 - Fatigue, a common symptom, together with the characteristic of performance fatigability, are well-documented features of SMA that impact quality of life and function. Importantly, establishing associations between multidimensional self-reported fatigue scales and patient performance has proven difficult. This review was conducted to evaluate the various patient-reported fatigue scales applied in SMA, with the objective of considering the limitations and advantages of each measure. Variable use of fatigue-related nomenclature, including conflicting terminology interpretation, has affected assessment of physical fatigue attributes, specifically perceived fatigability. This review encourages the development of original patient-reported scales to enable perceived fatigability assessment, providing a potential complementary method of evaluating treatment response.

AB - Fatigue, a common symptom, together with the characteristic of performance fatigability, are well-documented features of SMA that impact quality of life and function. Importantly, establishing associations between multidimensional self-reported fatigue scales and patient performance has proven difficult. This review was conducted to evaluate the various patient-reported fatigue scales applied in SMA, with the objective of considering the limitations and advantages of each measure. Variable use of fatigue-related nomenclature, including conflicting terminology interpretation, has affected assessment of physical fatigue attributes, specifically perceived fatigability. This review encourages the development of original patient-reported scales to enable perceived fatigability assessment, providing a potential complementary method of evaluating treatment response.

KW - SPINAL MUSCULAR ATROPHY

UR - http://hdl.handle.net/10807/235651

U2 - 10.3390/jcm12103458

DO - 10.3390/jcm12103458

M3 - Article

SN - 2077-0383

VL - 12

SP - N/A-N/A

JO - Journal of Clinical Medicine

JF - Journal of Clinical Medicine

ER -

Measuring Fatigue and Fatigability in Spinal Muscular Atrophy (SMA): Challenges and Opportunities

Abstract

Keywords

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