Concomitant primary cutaneous melanoma in monozygotic twins has been reported in only two pairs but in neither of them genetic analysis was performed. Two high-penetrance susceptibility genes, CDKN2A and CDK4 and one low-penetrance gene, MC1R, are well-defined genetic risk factors for melanoma. MITF has been recently identified as a novel intermediate risk melanoma-predisposing gene.
- Base Sequence
- Genetic Predisposition to Disease
- Genetic Variation
- Neoplasm Invasiveness
- Receptor, Melanocortin, Type 1
- Skin Neoplasms
- Twins, Monozygotic