May endovascular thrombectomy without CT perfusion improve clinical outcome?

Andrea M Alexandre, Alessandro Pedicelli, Iacopo Valente, Luca Scarcia, Francesca Giubbolini, Francesco D'Argento, Emilio Lozupone, Maria Grazia Distefano, Fabio Pilato, Cesare Colosimo

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Background: DAWN and DEFUSE-3 trials demonstrated the benefit of endovascular thrombectomy in late-presenting acute ischemic strokes due to anterior circulation large vessel occlusion. The aim of our study is to evaluate results of endovascular thrombectomy in large intracranial vessel occlusion without perfusion CT patient selection. Methods: we reviewed our prospectively collected endovascular databases for patients with an acute stroke from March 2016 to October 2018, treated after 6 h from stroke onset, without perfusion CT selection. Baseline characteristics, procedural data, and outcomes were evaluated. A good outcome was defined as a 90-day modified Rankin Scale score of 0–2. The association between clinical and procedural parameters and functional outcome was assessed. Results: out of 212 patients 55 were treated after 6 h from stroke onset, 49 of which for an anterior circulation occlusion. 18/49 were functional independent at 90 days (mRS 0–2), Successful recanalization (mTICI 2b to 3) was achieved in 38/49 patients (77 %). Multivariate logistic regression indicated that a low baseline NIHSS was associated with favorable outcome (OR 0.66, 95 % CI 0.52−0.83, p-value 0.001). Conclusions: in our retrospective analysis, baseline NIHSS is the only parameter that can predict good outcome (90-days mRS 0–2). We confirm data from recent papers assessing that perfusion CT can provide a better patients' selection compared to mCTA for large vessels occlusion treated beyond six hours from symptom onset.
Lingua originaleEnglish
pagine (da-a)106207-N/A
RivistaClinical Neurology and Neurosurgery
Stato di pubblicazionePubblicato - 2020


  • CT perfusion
  • Endovascular thrombectomy
  • Innovative biotechnologies
  • Stroke
  • Stroke after 6 hours


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