Massive foeto-maternal transfusion: how long are foetal blood cells detectable in the maternal circulation?

Fabrizio Signore, Laura Marchi, Nathalie Conti, Cinzia Orlandini, Annalisa Vidiri, Francesca Brugnolo, Franco Bambi, Simona Zaami, Giovanni Scambia, Anna F. Cavaliere, Anna Franca Cavaliere

Risultato della ricerca: Contributo in rivistaArticolo in rivista


Massive foeto-maternal transfusion (FMT) is the passage into the maternal circulation of >20% of foetal blood volume. It is associated with high perinatal morbidity and mortality1. FMT affects approximately 0.3-1:1,000 births and in non-complicated near-term pregnancies is frequently idiopathic1.Clinical manifestations are non-specific and are mostly represented by a decrease in active foetal movements (AFM). Foetal anaemia can be suggested by a sinusoidal rhythm on cardiotocography (CTG) and by high peak systolic velocity (PSV) of the middle cerebral artery (MCA); both tests, however, are liable to yield false negative results1. The conclusive diagnosis of FMT is based on maternal laboratory blood tests such as the Kleihauer-Betke, although the gold standard is currently flow cytometry which has been proven to be more sensitive and time-saving2. However, the latter test is not always available, and therefore FMT is to be considered when other possible origins of neonatal anaemia have been excluded. We aim to demonstrate the long-lasting persistence of foetal blood cells in the maternal circulation in a case of massive FMT. These data are useful in a clinical scenario when FMT is not immediately suspected or investigated.
Lingua originaleEnglish
pagine (da-a)338-340
Numero di pagine3
Stato di pubblicazionePubblicato - 2022


  • foeto-maternal transfusion
  • perinatal death
  • flow cytometry


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