Mass spectrometry applications in microbiology beyond microbe identification: progress and potential

Maurizio Sanguinetti*, Brunella Posteraro

*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivistaArticolo in rivista

15 Citazioni (Scopus)


Introduction: Mass spectrometry (MS), particularly MALDI-time of flight (MALDI-TOF), has become a routine tool for microorganism identification in clinical microbiology laboratories in the last five years. The use of MALDI-TOF MS has accelerated laboratory analysis, thus providing accurate species-level information with very short turnaround times. Areas covered: Beyond microbe identification, MALDI-TOF MS offers great opportunities for fast strain typing and detection of antimicrobial susceptibility/resistance in both bacterial and fungal organisms. Drawing on evidence from PubMed literature searches, clinical microbiology laboratory experience, and the authors’ opinions, this review summarizes recent significant advances and ongoing challenges in these areas. Expert commentary: In the near future, it is expected that the implementation of new analytical algorithms, automation of procedures, and refinement of assays will enhance the clinical and epidemiological usefulness of MALDI-TOF and other MS technologies.
Lingua originaleEnglish
pagine (da-a)965-977
Numero di pagine13
RivistaExpert Review of Proteomics
Stato di pubblicazionePubblicato - 2016


  • Antimicrobial susceptibility testing
  • Biochemistry
  • Molecular Biology
  • bacteria
  • clinical microbiology
  • fungi
  • mass spectrometry
  • microbial typing
  • resistance detection


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