Masked mycotoxins are efficiently hydrolyzed by human colonic microbiota releasing their aglycones

Margherita Dall'Asta, Andrea Dall'Erta, Martina Cirlini, Daniele Del Rio, Gianni Galaverna, Chiara Dall'Asta

Risultato della ricerca: Contributo in rivistaArticolo in rivista

130 Citazioni (Scopus)

Abstract

Fusarium mycotoxins are secondary metabolites produced by Fusarium spp. in cereals. Among them, deoxynivalenol (DON) and zearalenone (ZEN) are widespread worldwide contaminants of cereal commodities and are ranked as the most important chronic dietary risk factors. Their conjugates, known as masked mycotoxins, have been described but are still not accounted for in risk assessment studies. This study demonstrates for the first time that DON and ZEN are effectively deconjugated by the human colonic microbiota, releasing their toxic aglycones and generating yet unidentified catabolites. For this reason, masked mycotoxins should be considered when evaluating population exposure. © 2013 American Chemical Society.
Lingua originaleEnglish
pagine (da-a)305-312
Numero di pagine8
RivistaChemical Research in Toxicology
Volume26
DOI
Stato di pubblicazionePubblicato - 2013

Keywords

  • Masked mycotoxin
  • human digestion
  • microbiome

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