Management of Surgical Third Lower Molar Extraction and Postoperative Progress in Patients With Factor VII Deficiency: A Clinical Protocol and Focus on This Rare Pathologic Entity

Antonio D'Addona, Guido Pasquantonio

Risultato della ricerca: Contributo in rivistaArticolo in rivista

12 Citazioni (Scopus)

Abstract

Purpose The purpose of the present study was to analyze the management of surgical third molar extraction and postoperative progress in patients with a diagnosis of factor VII deficiency. Close collaboration between the oral-maxillofacial surgeon and hematologist will allow the team to categorize the risk and operate safely, thereby minimizing the incidence and severity of intraoperative and postoperative complications. Materials and Methods The present retrospective study included 7 patients with factor VII deficiency who had undergone third lower molar surgery. Their factor VII deficiency ranged from 10.5 to 21.0%. Recombinant activated factor VII (rFVIIa) (coagulation factor VIIa [recombinant]; NovoSeven RT; Novo Nordisk, Bagsvaerd, Denmark) was transfused intravenously in a single dose of 25 μg/kg body weight, 30 minutes before surgical extractions. After the surgery, betamethasone, an analgesic, and an ice pack were administered. Results Pretreatment with recombinant activated factor VII resulted in excellent hemostasis. No hemorrhagic complications and no postoperative major bleeding were observed. Conclusions The extraction of the third lower molar appears to be a safe procedure for patients with factor VII deficiency when appropriate prophylaxis with rFVIIa is used.
Lingua originaleEnglish
pagine (da-a)2070-2070.e4
RivistaJournal of Oral and Maxillofacial Surgery
Volume75
DOI
Stato di pubblicazionePubblicato - 2017

Keywords

  • Adult
  • Blood Loss, Surgical
  • Clinical Protocols
  • Factor VII Deficiency
  • Factor VIIa
  • Female
  • Humans
  • Male
  • Molar, Third
  • Oral Surgery
  • Otorhinolaryngology2734 Pathology and Forensic Medicine
  • Postoperative Hemorrhage
  • Recombinant Proteins
  • Retrospective Studies
  • Surgery
  • Tooth Extraction
  • Young Adult

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