Management of elderly patients with immune thrombocytopenia: Real-world evidence from 451 patients older than 60 years

Elena Rossi, Valerio De Stefano, Francesca Palandri, Cristina Santoro, Monica Carpenedo, Silvia Cantoni, Wilma Barcellini, Giuseppe Carli, Valentina Carrai, Elena Rivolti, Alessandro Lucchesi, Francesco Rotondo, Erminia Baldacci, Giuseppe Auteri, Emanuele Sutto, Christian Di Pietro, Lucia Catani, Daniela Bartoletti, Marco Ruggeri, Maria Gabriella MazzucconiMichele Cavo, Francesco Rodeghiero, Nicola Vianelli

Risultato della ricerca: Contributo in rivistaArticolo in rivista

2 Citazioni (Scopus)

Abstract

Introduction: Primary Immune thrombocytopenia (ITP) in the elderly is a major clinical challenge which is increasingly frequent due to global ageing population. Materials and methods: To describe baseline ITP features, management, and outcome, a centralized electronic database was established, including data of 451 patients aged ≥60 years that were treated from 2000 onwards and were observed for ≥1 year (total observation of 2704 patient-years). Results: At ITP diagnosis, median age was 71.1 years (age ≥ 75: 42.8%); 237 (53.9%) patients presented with haemorrhages (grade ≥ 3: 7.5%). First-line therapy included prednisone (82.9%), dexamethasone (14.6%), thrombopoietin-receptor agonists (TRAs, 1.3%), and oral immunosuppressive agents (1.1%). Prednisone starting dose ≥1 mg/kg/d (p = .01) and dexamethasone 40 mg/d (p < .001) were mainly reserved to patients aged 60–74, who were more treated with rituximab (RTX, p = .02) and splenectomy (p = .03) second-line. Overall response rates to first and second-line therapies were 83.8% and 84.5%, respectively, regardless of age and treatment type/dose. A total of 178 haemorrhages in 101 patients (grade ≥ 3: n. 52, 29.2%; intracranial in 6 patients), 49 thromboses in 43 patients (grade ≥ 3: n. 26, 53.1%) and 115 infections in 94 patients (grade ≥ 3: n. 23, 20%) were observed during follow-up. Incidence rates of complications per 100 patient-years were: 4.5 (haemorrhages, grade ≥ 3: 1.7), 1.7 (thromboses, grade ≥ 3: 0.9), and 3.9 (infections, grade ≥ 3: 0.7). TRAs use were associated with reduced risk of bleeding and infections, while cardiovascular risk factors (particularly, diabetes) significantly predicted thromboses and infections. Conclusions: Age-adapted treatment strategies are required in elderly and very elderly patients.
Lingua originaleEnglish
pagine (da-a)88-95
Numero di pagine8
RivistaThrombosis Research
Volume185
DOI
Stato di pubblicazionePubblicato - 2020

Keywords

  • Elderly
  • ITP
  • Immune thrombocytopenia
  • TPO-receptor agonists
  • Toxicity

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