Management of antibody-mediated autoimmune encephalitis in adults and children: literature review and consensus-based practical recommendations

Amelia Evoli, Raffaele Iorio, Luigi Zuliani, Margherita Nosadini, Matteo Gastaldi, Marianna Spatola, Marco Zoccarato, Sara Mariotto, Piera De Gaspari, Francesco Perini, Sergio Ferrari, Stefano Sartori, Diego Franciotta, Bruno Giometto

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Abstract Autoimmune encephalitis associated with antibodies against neuronal surface targets (NSAE) are rare but still underrecognized conditions that affect adult and pediatric patients. Clinical guidelines have recently been published with the aim of providing diagnostic clues regardless of antibody status. These syndromes are potentially treatable but the choice of treatment and its timing, as well as differential diagnoses, long-term management, and clinical and paraclinical follow-up, remain major challenges. In the absence of evidence-based guidelines, management of these conditions is commonly based on single-center expertise.Taking into account different published expert recommendations in addition to the multicenter experience of the Italian Working Group on Autoimmune Encephalitis, both widely accepted and critical aspects of diagnosis, management and particularly of immunotherapy for NSAE have been reviewed and are discussed.Finally, we provide consensus-based practical advice for managing hospitalization and follow-up of patients with NSAE.
Lingua originaleEnglish
pagine (da-a)2017-2030-2030
RivistaNeurological Sciences
Volume40
DOI
Stato di pubblicazionePubblicato - 2019

Keywords

  • Adult
  • Autoantibodies
  • Autoimmune encephalitis
  • Child
  • Encephalitis
  • Female
  • Hashimoto Disease
  • Humans
  • LGI1
  • Male
  • NMDAR
  • NSAE
  • NSAb

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