TY - JOUR
T1 - Malignant transformation of Madelung's disease in a patient with a coincidental diagnosis of breast cancer: a case report.
AU - Ferrandina, Maria Gabriella
AU - Lucidi, Alessandro
AU - Carbone, Arnaldo
AU - Iannone, Vito
AU - Borriello, Maddalena
PY - 2012
Y1 - 2012
N2 - Madelung's disease or multiple symmetric lipomatosis (MSL) is a rare disorder of unknown etiology which typically presents symmetrically subcutaneous accumulation of non-encapsulated adipose tissue which slowly grows around the neck, upper part of the arms, pelvis, back and thigh. This disease is also frequently associated with hepatopathy, glucose intolerance, hyperuricemia, and malignant tumors of the upper airways. Nevertheless, only one description of malignant transformation of Madelung's disease has been presented in literature. Here, we report a case of liposarcomatous transformation of Madelung's disease in a 59-year-old Italian woman with a coincidental diagnosis of breast cancer. VIRTUAL SLIDE: The virtual slide for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/3480884087499351.
AB - Madelung's disease or multiple symmetric lipomatosis (MSL) is a rare disorder of unknown etiology which typically presents symmetrically subcutaneous accumulation of non-encapsulated adipose tissue which slowly grows around the neck, upper part of the arms, pelvis, back and thigh. This disease is also frequently associated with hepatopathy, glucose intolerance, hyperuricemia, and malignant tumors of the upper airways. Nevertheless, only one description of malignant transformation of Madelung's disease has been presented in literature. Here, we report a case of liposarcomatous transformation of Madelung's disease in a 59-year-old Italian woman with a coincidental diagnosis of breast cancer. VIRTUAL SLIDE: The virtual slide for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/3480884087499351.
KW - Breast Neoplasms
KW - Carcinoma, Ductal, Breast
KW - Cell Transformation, Neoplastic
KW - Female
KW - Humans
KW - Lipomatosis, Multiple Symmetrical
KW - Liposarcoma
KW - Middle Aged
KW - Neoplasms, Multiple Primary
KW - Breast Neoplasms
KW - Carcinoma, Ductal, Breast
KW - Cell Transformation, Neoplastic
KW - Female
KW - Humans
KW - Lipomatosis, Multiple Symmetrical
KW - Liposarcoma
KW - Middle Aged
KW - Neoplasms, Multiple Primary
UR - http://hdl.handle.net/10807/63516
UR - http://www.diagnosticpathology.org/content/7/1/116
U2 - 10.1186/1746-1596-7-116
DO - 10.1186/1746-1596-7-116
M3 - Article
VL - 7
SP - 116
EP - 116
JO - Diagnostic Pathology
JF - Diagnostic Pathology
SN - 1746-1596
ER -