Male fertility and reduction in semen parameters: A single tertiary-care center experience

Domenico Milardi, Giuseppe Grande, Dario Sacchini, Anna Laura Astorri, Giuseppina Pompa, Antonella Giampietro, Laura De Marinis Grasso, Alfredo Pontecorvi, Antonio Gioacchino Spagnolo, Riccardo Marana

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

14 Citazioni (Scopus)


Background. Infertility is both a clinical and a public problem, affecting the life of the couple, the healthcare services, and social environment. Standard semen analysis is the surrogate measure of male fertility in clinical practice. Objective. To provide information about the relationship between semen parameters and spontaneous conception. Methods. We evaluated retrospectively 453 pregnancies that occurred among 2935 infertile couples evaluated at an infertility clinic of a tertiary-care university hospital, between 2004 and 2009. Results. Normal semen analysis was present only in 158 patients; 295 subfertile patients showed alterations in at least one seminal parameter. A reduction in all seminal parameters was observed in 41 patients. Etiological causes of male infertility were identified in 314 patients. Conclusion. Our data highlights the possibility of a spontaneous conception with semen parameters below WHO reference values. Therefore, we support the importance of defining reference values on a population of fertile men. Finally, we analyzed the related ethical issues. Copyright © 2012 D. Milardi et al.
Lingua originaleEnglish
pagine (da-a)1-6
Numero di pagine6
RivistaInternational Journal of Endocrinology
Stato di pubblicazionePubblicato - 2012


  • Mycoplasma hominis infection
  • Ureaplasma infection
  • adult
  • article
  • asthenospermia
  • conception
  • controlled study
  • female
  • human
  • hypogonadism
  • hypophysis disease
  • idiopathic disease
  • major clinical study
  • male
  • male genital tract infection
  • male genital tract parameters
  • male infertility
  • morphology
  • normal value
  • oligoasthenoteratospermia
  • priority journal
  • reference value
  • retrospective study
  • semen abnormality
  • semen analysis
  • semen parameters
  • spermatozoon count
  • spermatozoon motility
  • subfertility
  • teratospermia
  • tertiary health care
  • thyroid disease
  • varicocele
  • varicocelectomy


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