Main physiopathologic mechanisms involved in hepatic drug reactions

G Valentini, Esmeralda Capristo, Antonino Scarfone, Geltrude Mingrone, Av Greco, Giovanni Battista Gasbarrini

Risultato della ricerca: Contributo in rivistaArticolo in rivista

1 Citazioni (Scopus)


The liver has a pivotal role in drug metabolism and hepatic drug reactions are frequent events, accounting for 5% of cases of jaundice or acute hepatitis in the community. The importance of hepatic drug reactions lies not only in their frequency, but also in the great number of molecules that can cause this type of lesions and in their variable gravity. This review will show the main factors implicated in drug metabolism which can explain the different susceptibility in developing hepatic drug reaction, the possibility that it may manifest as a wide spectrum of clinical syndromes or that a single agent may cause more than one lesion (a relevant problem not only for the clinician, but also for the pathologist).
Lingua originaleEnglish
pagine (da-a)81-88
Numero di pagine8
RivistaMinerva Gastroenterologica e Dietologica
Stato di pubblicazionePubblicato - 2002


  • hepatic


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