Abstract
The relationship between magnesium and cancer is not as simple as could be assumed from the
well-established requirement of magnesium for cell proliferation. Basic and pre-clinical studies
indicate that magnesium deficiency can have both anti- and pro-tumour effects. In the present
review, we briefly outline the new findings on the role of magnesium in angiogenesis and
metastatization, and focus on the relationship between tumour cell proliferation and metabolic
reprogramming, discussing how magnesium and its transporters are involved in these processes.
The role of magnesium in cancer is also critically examined with regard to mitochondrial function,
apoptosis and resistance to treatment. Finally, we bring together the latest experimental evidence
indicating that alteration in the expression and/or activity of magnesium channels is a frequent
finding in cancer cells and human tumour tissues examined to date, and we discuss the potential
implications for developing novel diagnostic and therapeutic strategies.
Lingua originale | English |
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pagine (da-a) | 417-427 |
Numero di pagine | 11 |
Rivista | Clinical Science |
Stato di pubblicazione | Pubblicato - 2012 |
Keywords
- aerobic glycolysis
- apoptosis
- metabolism
- mrs2
- trpm6
- trpm7