Lysophosphatidic acid enhances antimycobacterial response during in vivo primary Mycobacterium tuberculosis infection

Giovanni Delogu; Michela Sali; Stefano Rocca; Gianluca Quintiliani; Marilina B. Santucci; Emanuela Greco; Andrea Cabibbo; Francesca Mariani; Vittorio Colizzi; Giovanni Fadda; Maurizio Fraziano

doi:10.1016/j.cellimm.2011.05.014

Lysophosphatidic acid enhances antimycobacterial response during in vivo primary Mycobacterium tuberculosis infection

Giovanni Delogu, Michela Sali, Stefano Rocca, Gianluca Quintiliani, Marilina B. Santucci, Emanuela Greco, Andrea Cabibbo, Francesca Mariani, Vittorio Colizzi, Giovanni Fadda, Maurizio Fraziano

Risultato della ricerca: Contributo in rivista › Articolo in rivista › peer review

4 Citazioni (Scopus)

Abstract

Lysophospholipids may play an important protective role during primary infection of Mycobacterium tuberculosis (MTB) by enhancing innate antimycobacterial immune response of both macrophages and alveolar epithelial cells. Here, we show that treatment with lysophosphatidic acid (LPA) of mice aerogenically infected with MTB immediately after infection results in a significant early reduction of pulmonary CFUs and of histopathological damage in comparison with control mice. In contrast, treatment of acute disease does not result in any improvement of both microbiological and histopathological parameters. Altogether, these results show that LPA treatment can exert protective effect if administrated during primary infection, only.

Lingua originale	English
pagine (da-a)	1-4
Numero di pagine	4
Rivista	Cellular Immunology
Volume	271
DOI	https://doi.org/10.1016/j.cellimm.2011.05.014
Stato di pubblicazione	Pubblicato - 2011

Keywords

Acute Disease
Animals
Colony Count, Microbial
Female
Lung
Lysophospholipids
Mice
Mice, Inbred BALB C
Mycobacterium tuberculosis
Sphingosine
Time Factors
Treatment Outcome
Tuberculosis, Pulmonary

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10.1016/j.cellimm.2011.05.014

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title = "Lysophosphatidic acid enhances antimycobacterial response during in vivo primary Mycobacterium tuberculosis infection",

abstract = "Lysophospholipids may play an important protective role during primary infection of Mycobacterium tuberculosis (MTB) by enhancing innate antimycobacterial immune response of both macrophages and alveolar epithelial cells. Here, we show that treatment with lysophosphatidic acid (LPA) of mice aerogenically infected with MTB immediately after infection results in a significant early reduction of pulmonary CFUs and of histopathological damage in comparison with control mice. In contrast, treatment of acute disease does not result in any improvement of both microbiological and histopathological parameters. Altogether, these results show that LPA treatment can exert protective effect if administrated during primary infection, only.",

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author = "Giovanni Delogu and Michela Sali and Stefano Rocca and Gianluca Quintiliani and Santucci, {Marilina B.} and Emanuela Greco and Andrea Cabibbo and Francesca Mariani and Vittorio Colizzi and Giovanni Fadda and Maurizio Fraziano",

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T1 - Lysophosphatidic acid enhances antimycobacterial response during in vivo primary Mycobacterium tuberculosis infection

AU - Delogu, Giovanni

AU - Sali, Michela

AU - Rocca, Stefano

AU - Quintiliani, Gianluca

AU - Santucci, Marilina B.

AU - Greco, Emanuela

AU - Cabibbo, Andrea

AU - Mariani, Francesca

AU - Colizzi, Vittorio

AU - Fadda, Giovanni

AU - Fraziano, Maurizio

PY - 2011

Y1 - 2011

N2 - Lysophospholipids may play an important protective role during primary infection of Mycobacterium tuberculosis (MTB) by enhancing innate antimycobacterial immune response of both macrophages and alveolar epithelial cells. Here, we show that treatment with lysophosphatidic acid (LPA) of mice aerogenically infected with MTB immediately after infection results in a significant early reduction of pulmonary CFUs and of histopathological damage in comparison with control mice. In contrast, treatment of acute disease does not result in any improvement of both microbiological and histopathological parameters. Altogether, these results show that LPA treatment can exert protective effect if administrated during primary infection, only.

AB - Lysophospholipids may play an important protective role during primary infection of Mycobacterium tuberculosis (MTB) by enhancing innate antimycobacterial immune response of both macrophages and alveolar epithelial cells. Here, we show that treatment with lysophosphatidic acid (LPA) of mice aerogenically infected with MTB immediately after infection results in a significant early reduction of pulmonary CFUs and of histopathological damage in comparison with control mice. In contrast, treatment of acute disease does not result in any improvement of both microbiological and histopathological parameters. Altogether, these results show that LPA treatment can exert protective effect if administrated during primary infection, only.

KW - Acute Disease

KW - Animals

KW - Colony Count, Microbial

KW - Female

KW - Lung

KW - Lysophospholipids

KW - Mice

KW - Mice, Inbred BALB C

KW - Mycobacterium tuberculosis

KW - Sphingosine

KW - Time Factors

KW - Treatment Outcome

KW - Tuberculosis, Pulmonary

KW - Acute Disease

KW - Animals

KW - Colony Count, Microbial

KW - Female

KW - Lung

KW - Lysophospholipids

KW - Mice

KW - Mice, Inbred BALB C

KW - Mycobacterium tuberculosis

KW - Sphingosine

KW - Time Factors

KW - Treatment Outcome

KW - Tuberculosis, Pulmonary

UR - http://hdl.handle.net/10807/4956

U2 - 10.1016/j.cellimm.2011.05.014

DO - 10.1016/j.cellimm.2011.05.014

M3 - Article

SN - 0008-8749

VL - 271

SP - 1

EP - 4

JO - Cellular Immunology

JF - Cellular Immunology

ER -

Lysophosphatidic acid enhances antimycobacterial response during in vivo primary Mycobacterium tuberculosis infection

Abstract

Keywords

OSS delle Nazioni Unite

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