Lycopene as a guardian of redox signalling

Paola Palozza, Assunta Catalano, Rossella Simone, Achille Renato Maria Cittadini

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

65 Citazioni (Scopus)


It has been suggested that lycopene, the major carotenoid found in tomato, exhibits health-beneficial effects by virtue of its antioxidant activity. However, recent literature suggests that lycopene can actually “perform” roles independent of such capacity and involving a direct modulation of redox signalling. Reactive oxygen species are known to act as second messengers in the modulation of cellular signalling leading to gene expression changes and pharmacological responses. Lycopene may control redox-sensitive molecular targets, affecting enzyme activities and expressions and modulating the activation of MAPKs and transcription factors, such as NF-κB and AP-1, Nrf2.
Lingua originaleEnglish
pagine (da-a)21-25
Numero di pagine5
RivistaActa Biochimica Polonica
Stato di pubblicazionePubblicato - 2012
Pubblicato esternamente


  • ROS


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