Abstract
It has been suggested that lycopene, the major carotenoid\r\nfound in tomato, exhibits health-beneficial effects\r\nby virtue of its antioxidant activity. However, recent literature\r\nsuggests that lycopene can actually “perform”\r\nroles independent of such capacity and involving a direct\r\nmodulation of redox signalling. Reactive oxygen\r\nspecies are known to act as second messengers in the\r\nmodulation of cellular signalling leading to gene expression\r\nchanges and pharmacological responses. Lycopene\r\nmay control redox-sensitive molecular targets, affecting\r\nenzyme activities and expressions and modulating the\r\nactivation of MAPKs and transcription factors, such as\r\nNF-κB and AP-1, Nrf2.
Lingua originale | Inglese |
---|---|
pagine (da-a) | 21-25 |
Numero di pagine | 5 |
Rivista | Acta Biochimica Polonica |
Numero di pubblicazione | 59 |
DOI | |
Stato di pubblicazione | Pubblicato - 2012 |
Pubblicato esternamente | Sì |
All Science Journal Classification (ASJC) codes
- Biochimica, Genetica, Biologia Molecolare Generali
Keywords
- ANTIOXIDANT
- LYCOPENE
- REDOX SIGNAL
- ROS