TY - JOUR
T1 - Lung-protective ventilation during Trendelenburg pneumoperitoneum surgery: A randomized clinical trial
AU - Grieco, Domenico Luca
AU - Russo, A.
AU - Anzellotti, G. M.
AU - Romano, B.
AU - Bongiovanni, F.
AU - Dell'Anna, Antonio Maria
AU - Mauti, L.
AU - Cascarano, L.
AU - Gallotta, Valerio
AU - Rosa, T.
AU - Varone, Francesco
AU - Menga, Luca Salvatore
AU - Polidori, L.
AU - D'Indinosante, M.
AU - Cappuccio, S.
AU - Galletta, C.
AU - Tortorella, L.
AU - Costantini, B.
AU - Gueli Alletti, Salvatore
AU - Sollazzi, Liliana
AU - Scambia, Giovanni
AU - Antonelli, Massimo
PY - 2023
Y1 - 2023
N2 - Study objective To assess the effects of a protective ventilation strategy during Trendelenburg pneumoperitoneum surgery on postoperative oxygenation. Designs: Parallel-group, randomized trial. Setting: Operating room of a university hospital, Italy. Patients: Morbidly obese patients undergoing Trendelenburg pneumoperitoneum gynaecological surgery. Interventions: Participants were randomized to standard (SV: tidal volume = 10 ml/kg of predicted body weight, PEEP = 5 cmH2O) or protective (PV: tidal volume = 6 ml/kg of predicted body weight, PEEP = 10 cmH2O, recruitment maneuvers) ventilation during anesthesia. Measurements: Primary outcome was PaO2/FiO2 one hour after extubation. Secondary outcomes included day-1 PaO2/FiO2, day-2 respiratory function and intraoperative respiratory/lung mechanics, assessed through esophageal manometry, end-expiratory lung volume (EELV) measurement and pressure-volume curves. Main results: Sixty patients were analyzed (31 in SV group, 29 in PV group). Median [IqR] tidal volume was 350 ml [300–360] in PV group and 525 [500–575] in SV group. Median PaO2/FiO2 one hour after extubation was 280 mmHg [246–364] in PV group vs. 298 [250–343] in SV group (p = 0.64). Day-1 PaO2/FiO2, day-2 forced vital capacity, FEV-1 and Tiffenau Index were not different between groups (all p > 0.10). Intraoperatively, 59% of patients showed complete airway closure during pneumoperitoneum, without difference between groups: median airway opening pressure was 17 cmH2O. In PV group, airway and transpulmonary driving pressure were lower (12 ± 5 cmH2O vs. 17 ± 7, p < 0.001; 9 ± 4 vs. 13 ± 7, p < 0.001), PaCO2 and respiratory rate were higher (48 ± 8 mmHg vs. 42 ± 12, p < 0.001; 23 ± 5 breaths/min vs. 16 ± 4, p < 0.001). Intraoperative EELV was similar between PV and SV group (1193 ± 258 ml vs. 1207 ± 368, p = 0.80); ratio of tidal volume to EELV was lower in PV group (0.45 ± 0.12 vs. 0.32 ± 0.09, p < 0.001). Conclusions: In obese patients undergoing Trendelenburg pneumoperitoneum surgery, PV did not improve postoperative oxygenation nor day-2 respiratory function. PV was associated with intraoperative respiratory mechanics indicating less injurious ventilation. The high prevalence of complete airway closure may have affected study results. Trial registration: Prospectively registered on http://clinicaltrials.gov NCT03157479 on May 17th, 2017.
AB - Study objective To assess the effects of a protective ventilation strategy during Trendelenburg pneumoperitoneum surgery on postoperative oxygenation. Designs: Parallel-group, randomized trial. Setting: Operating room of a university hospital, Italy. Patients: Morbidly obese patients undergoing Trendelenburg pneumoperitoneum gynaecological surgery. Interventions: Participants were randomized to standard (SV: tidal volume = 10 ml/kg of predicted body weight, PEEP = 5 cmH2O) or protective (PV: tidal volume = 6 ml/kg of predicted body weight, PEEP = 10 cmH2O, recruitment maneuvers) ventilation during anesthesia. Measurements: Primary outcome was PaO2/FiO2 one hour after extubation. Secondary outcomes included day-1 PaO2/FiO2, day-2 respiratory function and intraoperative respiratory/lung mechanics, assessed through esophageal manometry, end-expiratory lung volume (EELV) measurement and pressure-volume curves. Main results: Sixty patients were analyzed (31 in SV group, 29 in PV group). Median [IqR] tidal volume was 350 ml [300–360] in PV group and 525 [500–575] in SV group. Median PaO2/FiO2 one hour after extubation was 280 mmHg [246–364] in PV group vs. 298 [250–343] in SV group (p = 0.64). Day-1 PaO2/FiO2, day-2 forced vital capacity, FEV-1 and Tiffenau Index were not different between groups (all p > 0.10). Intraoperatively, 59% of patients showed complete airway closure during pneumoperitoneum, without difference between groups: median airway opening pressure was 17 cmH2O. In PV group, airway and transpulmonary driving pressure were lower (12 ± 5 cmH2O vs. 17 ± 7, p < 0.001; 9 ± 4 vs. 13 ± 7, p < 0.001), PaCO2 and respiratory rate were higher (48 ± 8 mmHg vs. 42 ± 12, p < 0.001; 23 ± 5 breaths/min vs. 16 ± 4, p < 0.001). Intraoperative EELV was similar between PV and SV group (1193 ± 258 ml vs. 1207 ± 368, p = 0.80); ratio of tidal volume to EELV was lower in PV group (0.45 ± 0.12 vs. 0.32 ± 0.09, p < 0.001). Conclusions: In obese patients undergoing Trendelenburg pneumoperitoneum surgery, PV did not improve postoperative oxygenation nor day-2 respiratory function. PV was associated with intraoperative respiratory mechanics indicating less injurious ventilation. The high prevalence of complete airway closure may have affected study results. Trial registration: Prospectively registered on http://clinicaltrials.gov NCT03157479 on May 17th, 2017.
KW - General anesthesia
KW - Lung volumes
KW - Respiratory mechanics
KW - Obesity
KW - Mechanical ventilation
KW - General anesthesia
KW - Lung volumes
KW - Respiratory mechanics
KW - Obesity
KW - Mechanical ventilation
UR - http://hdl.handle.net/10807/305399
U2 - 10.1016/j.jclinane.2022.111037
DO - 10.1016/j.jclinane.2022.111037
M3 - Article
SN - 0952-8180
VL - 85
SP - N/A-N/A
JO - Journal of Clinical Anesthesia
JF - Journal of Clinical Anesthesia
ER -