Low plasma concentrations of albumin influence the affinity column-mediated immunoassay method for the measurement of tacrolimus in blood during the early period after liver transplantation

Enrico Di Stasio, Massimo Tempestilli, Maria Rosaria Basile, Federica Elisei, Mario Antonini, Giuseppe Maria Ettorre, Massimo Iappelli, Leopoldo Paolo Pucillo

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

11 Citazioni (Scopus)

Abstract

Monitoring of tacrolimus (TAC) concentrations in transplanted patients is necessary to ensure effective immunosuppression and to avoid adverse side effects. The fully automated analysis of TAC by the affinity column-mediated immunoassay (ACMIA), which does not require a precipitation step, may represent an efficient alternative to liquid chromatography-tandem mass spectrometry (LC-MS/MS), including in the clinically urgent situation. The aim of this work was to compare the analytical performances of ACMIA with those of LC-MS/MS and to evaluate the influence of hematological parameters, time posttransplant, and type of transplant on the results obtained from routine blood samples.
Lingua originaleEnglish
pagine (da-a)96-100
Numero di pagine5
RivistaTherapeutic Drug Monitoring
Volume35
DOI
Stato di pubblicazionePubblicato - 2013

Keywords

  • Adult
  • Aged
  • Chromatography, Liquid
  • Drug Monitoring
  • Female
  • Humans
  • Immunoassay
  • Immunosuppressive Agents
  • Kidney Transplantation
  • Liver Transplantation
  • Male
  • Middle Aged
  • Serum Albumin
  • Tacrolimus
  • Tandem Mass Spectrometry

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