Low levels of 25(OH)D and insulin-resistance: 2 unrelated features or a cause-effect in PCOS?

Giovanna Muscogiuri, Caterina Policola, Annamaria Prioletta, Gianpio Sorice, Teresa Mezza, Anna Pia Lassandro, Silvia Della Casa, Alfredo Pontecorvi, Andrea Giaccari

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61 Citazioni (SciVal)


BACKGROUND & AIMS: Recent investigations have identified low vitamin D status as a hypothetical mechanism of insulin-resistance in Polycystic Ovary Syndrome (PCOS). Instead, some authors supported the hypothesis that low vitamin D levels and insulin-resistance are 2 unrelated features of body size in PCOS. Hence, we aimed to explore the association of 25-hydroxyvitamin D (25(OH)D) with anthropometric, metabolic and hormonal features in PCOS. METHODS: We assessed the association of low 25(OH)D levels with endocrine parameters, insulin-sensitivity evaluated by hyperinsulinemic euglycemic clamp (HEC) and body composition measured by DEXA in 38 women affected by PCOS. RESULTS: Low 25(OH)D (25(OH)D < 50 nmo/L) was detected in 37% of the entire cohort of patients. Body Mass Index (BMI), in particular total fat mass (p < 0.001), resulted to be the most predictor factor of 25(OH)D levels whereas Sex Hormone Binding Globulin (SHBG), Free Androgen Index (FAI), glucose uptake and fat free mass were not. CONCLUSIONS: Our data demonstrated that in PCOS low 25(OH)D levels are significantly determined by the degree of adiposity.
Lingua originaleEnglish
pagine (da-a)N/A-N/A
Numero di pagine5
RivistaClinical Nutrition
Stato di pubblicazionePubblicato - 2012


  • BMI
  • PCOS
  • fat mass
  • insulin resistance
  • obesity
  • vitamin d


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