Low frequency of cigarette smoking and the risk of head and neck cancer in the INHANCE consortium pooled analysis.

J Berthiller; K Straif; A Agudo; W Ahrens; A Bezerra Dos Santos; Stefania Boccia; Gabriella Cadoni; Chiara Canova; X Castellsague; Chen Chen; D Conway; Mp Curado; L Dal Maso; Aw Daudt; E Fabianova; L Fernandez; S Franceschi; Ee Fukuyama; Rb Hayes; C Healy; R Herrero; I Holcatova; K Kelsey; K Kjaerheim; S Koifman; P Lagiou; C La Vecchia; P Lazarus; F Levi; J Lissowska; T Macfarlane; D Mates; M Mcclean; A Menezes; F Merletti; H Morgenstern; J Muscat; Af Olshan; M Purdue; H Ramroth; P Rudnai; Sm Schwartz; D Serraino; O Shangina; E Smith; Em Sturgis; N Szeszenia Dabrowska; P Thomson; Tl Vaughan; M Vilensky; Q Wei; Dm Winn; V Wünsch Filho; Zf Zhang; A Znaor; Giorgia Ferro; P Brennan; Paolo Boffetta; M Hashibe; Yc50 Lee

doi:10.1093/ije/dyv146

Low frequency of cigarette smoking and the risk of head and neck cancer in the INHANCE consortium pooled analysis.

J Berthiller, K Straif, A Agudo, W Ahrens, A Bezerra Dos Santos, Stefania Boccia, Gabriella Cadoni, Chiara Canova, X Castellsague, Chen Chen, D Conway, Mp Curado, L Dal Maso, Aw Daudt, E Fabianova, L Fernandez, S Franceschi, Ee Fukuyama, Rb Hayes, C HealyR Herrero, I Holcatova, K Kelsey, K Kjaerheim, S Koifman, P Lagiou, C La Vecchia, P Lazarus, F Levi, J Lissowska, T Macfarlane, D Mates, M Mcclean, A Menezes, F Merletti, H Morgenstern, J Muscat, Af Olshan, M Purdue, H Ramroth, P Rudnai, Sm Schwartz, D Serraino, O Shangina, E Smith, Em Sturgis, N Szeszenia Dabrowska, P Thomson, Tl Vaughan, M Vilensky, Q Wei, Dm Winn, V Wünsch Filho, Zf Zhang, A Znaor, Giorgia Ferro, P Brennan, Paolo Boffetta, M Hashibe, Yc50 Lee^*

^*Autore corrispondente per questo lavoro

Icahn School of Medicine at Mount Sinai

Risultato della ricerca: Contributo in rivista › Articolo

30 Citazioni (Scopus)

Abstract

BACKGROUND:\r\nCigarette smoking is a major risk factor for head and neck cancer (HNC). To our knowledge, low cigarette smoking (<10 cigarettes per day) has not been extensively investigated in fine categories or among never alcohol drinkers.\r\nMETHODS:\r\nWe conducted a pooled analysis of individual participant data from 23 independent case-control studies including 19 660 HNC cases and 25 566 controls. After exclusion of subjects using other tobacco products including cigars, pipes, snuffed or chewed tobacco and straw cigarettes (tobacco product used in Brazil), as well as subjects smoking more than 10 cigarettes per day, 4093 HNC cases and 13 416 controls were included in the analysis. The lifetime average frequency of cigarette consumption was categorized as follows: never cigarette users, >0-3, >3-5, >5-10 cigarettes per day.\r\nRESULTS:\r\nSmoking >0-3 cigarettes per day was associated with a 50% increased risk of HNC in the study population [odds ratio (OR) = 1.52, 95% confidence interval (CI): (1.21, 1.90). Smoking >3-5 cigarettes per day was associated in each subgroup from OR = 2.01 (95% CI: 1.22, 3.31) among never alcohol drinkers to OR = 2.74 (95% CI: 2.01, 3.74) among women and in each cancer site, particularly laryngeal cancer (OR = 3.48, 95% CI: 2.40, 5.05). However, the observed increased risk of HNC for low smoking frequency was not found among smokers with smoking duration shorter than 20 years.\r\nCONCLUSION:\r\nOur results suggest a public health message that low frequency of cigarette consumption contributes to the development of HNC. However, smoking duration seems to play at least an equal or a stronger role in the development of HNC.\r\n© The Author 2015; all rights reserved. Published by Oxford University Press on behalf of the International Epidemiological Association.\r\n\r\nKEYWORDS:\r\nHead and neck cancer; low frequency cigarette smoking; pooled analysis; risk factors

Lingua originale	Inglese
pagine (da-a)	835-845
Numero di pagine	11
Rivista	International Journal of Epidemiology
Volume	45
Numero di pubblicazione	3
DOI	https://doi.org/10.1093/ije/dyv146
Stato di pubblicazione	Pubblicato - 2016

All Science Journal Classification (ASJC) codes

Epidemiologia

Keywords

head and neck cancer

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10.1093/ije/dyv146

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Berthiller, J., Straif, K., Agudo, A., Ahrens, W., Bezerra Dos Santos, A., Boccia, S., Cadoni, G., Canova, C., Castellsague, X., Chen, C., Conway, D., Curado, M., Dal Maso, L., Daudt, A., Fabianova, E., Fernandez, L., Franceschi, S., Fukuyama, E., Hayes, R., ... Lee, Y. (2016). Low frequency of cigarette smoking and the risk of head and neck cancer in the INHANCE consortium pooled analysis. International Journal of Epidemiology, 45(3), 835-845. https://doi.org/10.1093/ije/dyv146

@article{d058f3b64fc54d8ca93e1bde01d5fe7e,

title = "Low frequency of cigarette smoking and the risk of head and neck cancer in the INHANCE consortium pooled analysis.",

abstract = "BACKGROUND:\textbackslash{}r\textbackslash{}nCigarette smoking is a major risk factor for head and neck cancer (HNC). To our knowledge, low cigarette smoking (<10 cigarettes per day) has not been extensively investigated in fine categories or among never alcohol drinkers.\textbackslash{}r\textbackslash{}nMETHODS:\textbackslash{}r\textbackslash{}nWe conducted a pooled analysis of individual participant data from 23 independent case-control studies including 19 660 HNC cases and 25 566 controls. After exclusion of subjects using other tobacco products including cigars, pipes, snuffed or chewed tobacco and straw cigarettes (tobacco product used in Brazil), as well as subjects smoking more than 10 cigarettes per day, 4093 HNC cases and 13 416 controls were included in the analysis. The lifetime average frequency of cigarette consumption was categorized as follows: never cigarette users, >0-3, >3-5, >5-10 cigarettes per day.\textbackslash{}r\textbackslash{}nRESULTS:\textbackslash{}r\textbackslash{}nSmoking >0-3 cigarettes per day was associated with a 50\% increased risk of HNC in the study population [odds ratio (OR) = 1.52, 95\% confidence interval (CI): (1.21, 1.90). Smoking >3-5 cigarettes per day was associated in each subgroup from OR = 2.01 (95\% CI: 1.22, 3.31) among never alcohol drinkers to OR = 2.74 (95\% CI: 2.01, 3.74) among women and in each cancer site, particularly laryngeal cancer (OR = 3.48, 95\% CI: 2.40, 5.05). However, the observed increased risk of HNC for low smoking frequency was not found among smokers with smoking duration shorter than 20 years.\textbackslash{}r\textbackslash{}nCONCLUSION:\textbackslash{}r\textbackslash{}nOur results suggest a public health message that low frequency of cigarette consumption contributes to the development of HNC. However, smoking duration seems to play at least an equal or a stronger role in the development of HNC.\textbackslash{}r\textbackslash{}n{\textcopyright} The Author 2015; all rights reserved. Published by Oxford University Press on behalf of the International Epidemiological Association.\textbackslash{}r\textbackslash{}n\textbackslash{}r\textbackslash{}nKEYWORDS:\textbackslash{}r\textbackslash{}nHead and neck cancer; low frequency cigarette smoking; pooled analysis; risk factors",

keywords = "head and neck cancer, head and neck cancer",

author = "J Berthiller and K Straif and A Agudo and W Ahrens and \{Bezerra Dos Santos\}, A and Stefania Boccia and Gabriella Cadoni and Chiara Canova and X Castellsague and Chen Chen and D Conway and Mp Curado and \{Dal Maso\}, L and Aw Daudt and E Fabianova and L Fernandez and S Franceschi and Ee Fukuyama and Rb Hayes and C Healy and R Herrero and I Holcatova and K Kelsey and K Kjaerheim and S Koifman and P Lagiou and \{La Vecchia\}, C and P Lazarus and F Levi and J Lissowska and T Macfarlane and D Mates and M Mcclean and A Menezes and F Merletti and H Morgenstern and J Muscat and Af Olshan and M Purdue and H Ramroth and P Rudnai and Sm Schwartz and D Serraino and O Shangina and E Smith and Em Sturgis and \{Szeszenia Dabrowska\}, N and P Thomson and Tl Vaughan and M Vilensky and Q Wei and Dm Winn and \{W{\"u}nsch Filho\}, V and Zf Zhang and A Znaor and Giorgia Ferro and P Brennan and Paolo Boffetta and M Hashibe and Yc50 Lee",

year = "2016",

doi = "10.1093/ije/dyv146",

language = "English",

volume = "45",

pages = "835--845",

journal = "International Journal of Epidemiology",

issn = "0300-5771",

publisher = "Oxford University Press",

number = "3",

}

Berthiller, J, Straif, K, Agudo, A, Ahrens, W, Bezerra Dos Santos, A, Boccia, S , Cadoni, G, Canova, C, Castellsague, X, Chen, C, Conway, D, Curado, M, Dal Maso, L, Daudt, A, Fabianova, E, Fernandez, L, Franceschi, S, Fukuyama, E, Hayes, R, Healy, C, Herrero, R, Holcatova, I, Kelsey, K, Kjaerheim, K, Koifman, S, Lagiou, P, La Vecchia, C, Lazarus, P, Levi, F, Lissowska, J, Macfarlane, T, Mates, D, Mcclean, M, Menezes, A, Merletti, F, Morgenstern, H, Muscat, J, Olshan, A, Purdue, M, Ramroth, H, Rudnai, P, Schwartz, S, Serraino, D, Shangina, O, Smith, E, Sturgis, E, Szeszenia Dabrowska, N, Thomson, P, Vaughan, T, Vilensky, M, Wei, Q, Winn, D, Wünsch Filho, V, Zhang, Z, Znaor, A, Ferro, G, Brennan, P, Boffetta, P, Hashibe, M & Lee, Y 2016, 'Low frequency of cigarette smoking and the risk of head and neck cancer in the INHANCE consortium pooled analysis.', International Journal of Epidemiology, vol. 45, n. 3, pagg. 835-845. https://doi.org/10.1093/ije/dyv146

TY - JOUR

T1 - Low frequency of cigarette smoking and the risk of head and neck cancer in the INHANCE consortium pooled analysis.

AU - Berthiller, J

AU - Straif, K

AU - Agudo, A

AU - Ahrens, W

AU - Bezerra Dos Santos, A

AU - Boccia, Stefania

AU - Cadoni, Gabriella

AU - Canova, Chiara

AU - Castellsague, X

AU - Chen, Chen

AU - Conway, D

AU - Curado, Mp

AU - Dal Maso, L

AU - Daudt, Aw

AU - Fabianova, E

AU - Fernandez, L

AU - Franceschi, S

AU - Fukuyama, Ee

AU - Hayes, Rb

AU - Healy, C

AU - Herrero, R

AU - Holcatova, I

AU - Kelsey, K

AU - Kjaerheim, K

AU - Koifman, S

AU - Lagiou, P

AU - La Vecchia, C

AU - Lazarus, P

AU - Levi, F

AU - Lissowska, J

AU - Macfarlane, T

AU - Mates, D

AU - Mcclean, M

AU - Menezes, A

AU - Merletti, F

AU - Morgenstern, H

AU - Muscat, J

AU - Olshan, Af

AU - Purdue, M

AU - Ramroth, H

AU - Rudnai, P

AU - Schwartz, Sm

AU - Serraino, D

AU - Shangina, O

AU - Smith, E

AU - Sturgis, Em

AU - Szeszenia Dabrowska, N

AU - Thomson, P

AU - Vaughan, Tl

AU - Vilensky, M

AU - Wei, Q

AU - Winn, Dm

AU - Wünsch Filho, V

AU - Zhang, Zf

AU - Znaor, A

AU - Ferro, Giorgia

AU - Brennan, P

AU - Boffetta, Paolo

AU - Hashibe, M

AU - Lee, Yc50

PY - 2016

Y1 - 2016

N2 - BACKGROUND:\r\nCigarette smoking is a major risk factor for head and neck cancer (HNC). To our knowledge, low cigarette smoking (<10 cigarettes per day) has not been extensively investigated in fine categories or among never alcohol drinkers.\r\nMETHODS:\r\nWe conducted a pooled analysis of individual participant data from 23 independent case-control studies including 19 660 HNC cases and 25 566 controls. After exclusion of subjects using other tobacco products including cigars, pipes, snuffed or chewed tobacco and straw cigarettes (tobacco product used in Brazil), as well as subjects smoking more than 10 cigarettes per day, 4093 HNC cases and 13 416 controls were included in the analysis. The lifetime average frequency of cigarette consumption was categorized as follows: never cigarette users, >0-3, >3-5, >5-10 cigarettes per day.\r\nRESULTS:\r\nSmoking >0-3 cigarettes per day was associated with a 50% increased risk of HNC in the study population [odds ratio (OR) = 1.52, 95% confidence interval (CI): (1.21, 1.90). Smoking >3-5 cigarettes per day was associated in each subgroup from OR = 2.01 (95% CI: 1.22, 3.31) among never alcohol drinkers to OR = 2.74 (95% CI: 2.01, 3.74) among women and in each cancer site, particularly laryngeal cancer (OR = 3.48, 95% CI: 2.40, 5.05). However, the observed increased risk of HNC for low smoking frequency was not found among smokers with smoking duration shorter than 20 years.\r\nCONCLUSION:\r\nOur results suggest a public health message that low frequency of cigarette consumption contributes to the development of HNC. However, smoking duration seems to play at least an equal or a stronger role in the development of HNC.\r\n© The Author 2015; all rights reserved. Published by Oxford University Press on behalf of the International Epidemiological Association.\r\n\r\nKEYWORDS:\r\nHead and neck cancer; low frequency cigarette smoking; pooled analysis; risk factors

AB - BACKGROUND:\r\nCigarette smoking is a major risk factor for head and neck cancer (HNC). To our knowledge, low cigarette smoking (<10 cigarettes per day) has not been extensively investigated in fine categories or among never alcohol drinkers.\r\nMETHODS:\r\nWe conducted a pooled analysis of individual participant data from 23 independent case-control studies including 19 660 HNC cases and 25 566 controls. After exclusion of subjects using other tobacco products including cigars, pipes, snuffed or chewed tobacco and straw cigarettes (tobacco product used in Brazil), as well as subjects smoking more than 10 cigarettes per day, 4093 HNC cases and 13 416 controls were included in the analysis. The lifetime average frequency of cigarette consumption was categorized as follows: never cigarette users, >0-3, >3-5, >5-10 cigarettes per day.\r\nRESULTS:\r\nSmoking >0-3 cigarettes per day was associated with a 50% increased risk of HNC in the study population [odds ratio (OR) = 1.52, 95% confidence interval (CI): (1.21, 1.90). Smoking >3-5 cigarettes per day was associated in each subgroup from OR = 2.01 (95% CI: 1.22, 3.31) among never alcohol drinkers to OR = 2.74 (95% CI: 2.01, 3.74) among women and in each cancer site, particularly laryngeal cancer (OR = 3.48, 95% CI: 2.40, 5.05). However, the observed increased risk of HNC for low smoking frequency was not found among smokers with smoking duration shorter than 20 years.\r\nCONCLUSION:\r\nOur results suggest a public health message that low frequency of cigarette consumption contributes to the development of HNC. However, smoking duration seems to play at least an equal or a stronger role in the development of HNC.\r\n© The Author 2015; all rights reserved. Published by Oxford University Press on behalf of the International Epidemiological Association.\r\n\r\nKEYWORDS:\r\nHead and neck cancer; low frequency cigarette smoking; pooled analysis; risk factors

KW - head and neck cancer

UR - https://publicatt.unicatt.it/handle/10807/111885

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U2 - 10.1093/ije/dyv146

DO - 10.1093/ije/dyv146

M3 - Article

SN - 0300-5771

VL - 45

SP - 835

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JO - International Journal of Epidemiology

JF - International Journal of Epidemiology

IS - 3

ER -

Low frequency of cigarette smoking and the risk of head and neck cancer in the INHANCE consortium pooled analysis.

Abstract

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