Low-dose radiotherapy and concurrent FOLFIRI-bevacizumab: A Phase II study

Alessio Giuseppe Morganti, Francesco Cellini*, Samantha Mignogna, Gilbert Da Padula, Luciana Caravatta, Francesco Deodato, Vincenzo Picardi, Gabriella Macchia, Savino Cilla, Milly Buwenge, Liberato Di Lullo, Maria Antonietta Gambacorta, Mario Balducci, Gian Carlo Mattiucci, Rosa Autorino, Vincenzo Valentini

*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivistaArticolo in rivista

2 Citazioni (Scopus)


Aims: Low-dose radiation therapy (LDRT) can increase biological efficacy of chemotherapy. This Phase II trial evaluates LDRT plus FOLFIRI-bevacizumab (FOLFIRI-B) in metastatic colorectal cancer. Materials & methods: Primary objective: raising the clinical complete response rate from 5 to 25%. Secondary objectives: toxicity, progression-free survival. Patients underwent 12 FOLFIRI-B cycles plus two daily LDRT fractions (20 cGy/6 h interval) on each cycle. Statistical analysis was planned on 18 patients. Results: Results on 18 patients are reported. Specifically considering irradiated sites: 15/18 patients had a partial (11/18) or complete (4/18) response. Among 11 partial responders, three became a pathological CR after surgery. Grade 3-4 toxicity was recorded in two patients (11.1%). At median follow-up of 30 months (range: 8-50), 7/18 patients progressed in irradiated sites. Conclusion: Seven out of 18 patients (38.9%) had clinical or pathological CR in lesions treated with LDRT. Further studies on this newer treatment modality seem justified.
Lingua originaleEnglish
pagine (da-a)779-787
Numero di pagine9
RivistaFuture Oncology
Stato di pubblicazionePubblicato - 2016


  • Adult
  • Aged
  • Antineoplastic Combined Chemotherapy Protocols
  • Bevacizumab
  • Camptothecin
  • Cancer Research
  • Chemoradiotherapy
  • Colorectal Neoplasms
  • Female
  • Fluorouracil
  • Humans
  • Leucovorin
  • Male
  • Middle Aged
  • Neoplasm Metastasis
  • Neoplasm Staging
  • Oncology
  • Phase II
  • Radiotherapy Dosage
  • Treatment Outcome
  • bevacizumab
  • chemo-sensitization
  • low-dose radiotherapy
  • metastatic colorectal cancer
  • multidisciplinary integrated treatments


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