TY - JOUR
T1 - Low- and high-frequency subcortical SEP amplitude reduction during pure passive movement.
AU - Insola, Angelo
AU - Padua, Luca
AU - Mazzone, Paolo
AU - Valeriani, Massimiliano
PY - 2015
Y1 - 2015
N2 - Objectives: To investigate the effect of pure passive movement on both cortical and subcortical
somatosensory evoked potentials (SEPs).
Methods: Median nerve SEPs were recorded in 8 patients suffering from Parkinson’s disease (PD) and two
patients with essential tremor. PD patients underwent electrode implantation in the subthalamic (STN)
nucleus (3 patients) and pedunculopontine (PPTg) nucleus (5 patients), while 2 patients with essential
tremor were implanted in the ventral intermediate nucleus (VIM) of the thalamus. In anesthetized
patients, SEPs were recorded at rest and during a passive movement of the thumb of the stimulated wrist
from the intracranial electrode contacts and from the scalp. Also the high-frequency oscillations (HFOs)
were analyzed.
Results: Amplitudes of both deep and scalp components were decreased during passive movement, but
the reduction was higher at cortical than subcortical level. Also the HFOs were reduced by movement.
Conclusion: The different amount of the movement-related decrease suggests that the cortical SEP gating
is not only the result of a subcortical somatosensory volley attenuation, but a further mechanism acting
at cortical level should be considered.
Significance: Our results are important for understanding the physiological mechanism of the sensory–
motor interaction during passive movement.
2015 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights
reserved.
AB - Objectives: To investigate the effect of pure passive movement on both cortical and subcortical
somatosensory evoked potentials (SEPs).
Methods: Median nerve SEPs were recorded in 8 patients suffering from Parkinson’s disease (PD) and two
patients with essential tremor. PD patients underwent electrode implantation in the subthalamic (STN)
nucleus (3 patients) and pedunculopontine (PPTg) nucleus (5 patients), while 2 patients with essential
tremor were implanted in the ventral intermediate nucleus (VIM) of the thalamus. In anesthetized
patients, SEPs were recorded at rest and during a passive movement of the thumb of the stimulated wrist
from the intracranial electrode contacts and from the scalp. Also the high-frequency oscillations (HFOs)
were analyzed.
Results: Amplitudes of both deep and scalp components were decreased during passive movement, but
the reduction was higher at cortical than subcortical level. Also the HFOs were reduced by movement.
Conclusion: The different amount of the movement-related decrease suggests that the cortical SEP gating
is not only the result of a subcortical somatosensory volley attenuation, but a further mechanism acting
at cortical level should be considered.
Significance: Our results are important for understanding the physiological mechanism of the sensory–
motor interaction during passive movement.
2015 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights
reserved.
KW - Gating Deep brain stimulation
KW - High frequency oscillations
KW - Sensory–motor interaction
KW - Somatosensory evoked potential
KW - Gating Deep brain stimulation
KW - High frequency oscillations
KW - Sensory–motor interaction
KW - Somatosensory evoked potential
UR - http://hdl.handle.net/10807/67221
U2 - 10.1016/j.clinph.2015.03.021
DO - 10.1016/j.clinph.2015.03.021
M3 - Article
SN - 1872-8952
VL - 126
SP - 2366
EP - 2375
JO - Clinical Neurophysiology
JF - Clinical Neurophysiology
ER -